Journal of Health and Quality of Life

Suggesting Priorities of Sustainable Development Goals Considering the Lingering Impacts of COVID-19

Jenny In — 2024-08-16

The Sustainable Development Goals (SDGs), aimed to be achieved by 2030, demand a more efficient approach for the remaining period due to the currently low achievement rate and the persisting impact of COVID-19. Consequently, this study analyzes United Nations statistics and previous studies to propose a global prioritization of SDGs. The arguments in each document were interpreted cross-sectionally with those of others. The analysis incorporates a simple system dynamics methodology and adds a national psychological and behavioral economic perspective. Among all SDGs, this study suggests that Goal 17 (Partnerships for the Goals) and ecosystem-related goals corresponding to Goals 13, 14, and 15 should be the foremost global priorities, given their capacity to establish the foundation for other goals. The general goals (Goals 1 to 9, 11, 12, and 16) and Goal 10 (Reduced Inequalities) follow as the subsequent priorities, fostering the most effective progression. The paper also suggests that among the targets of Goal 17, targets 17.2 (fully implement the commitment to Official Development Assistance), 17.18 (support available data to developing countries), and 17.11 (increase exports of developing countries) should be globally prioritized to focus on the economic recovery of developing countries in a short time. Furthermore, this study recommends that while each region maintains its local priorities, the international community should adhere to the global priorities presented. This alignment will lead to a worldwide virtuous circle—a structure where following each other's priorities helps resolve the next set of issues.

Unveiling the Landscape of Acute Kidney Injury in Surgical Patients: A Systematic Review of Risk Factors and Clinical Biomarkers

Nooreena Yusop — 2024-08-16

Acute Kidney Injury (AKI) is a critical complication with significant implications for surgical patients, leading to increased morbidity, mortality, and healthcare costs. Identifying the risk factors and clinical biomarkers associated with AKI in the surgical context is essential for timely intervention and personalized management. To address this knowledge gap, we conducted a systematic review to comprehensively analyze existing literature on AKI in surgical patients. In this paper, we provided a systemically review analysis based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) technique for AKI risk factors and clinical biomarkers. The advanced searching into two powerful databases which is Scopus, Pubmed and Mendeley. Based on searching, find finally main data n=30 and will be analyzed using the synthesis approach. Through a meticulous search and appraisal of studies in reputable scientific databases, we identified a diverse range of research articles, clinical trials, and cohort studies that met our rigorous inclusion criteria. Synthesizing the findings from these studies, we explored the multifactorial nature of AKI, encompassing patient-related factors, surgical variables, and exposure to potential nephrotoxic agents. Our review revealed that AKI in surgical patients is influenced by a complex interplay of risk factors, including patient demographics, comorbidities, surgical procedures, anaesthetic management, and exposure to nephrotoxic drugs. The systematic analysis identified the most common drug classes associated with drug-induced AKI, such as diuretics, ACE inhibitors/angiotensin receptor blockers (ACEIs/ARBs), and antibiotics

The Effectiveness of GIS Mobility based Pattern Recognition Approach in COVID19 Infection among Sabah Local Community

Ang Kean Hua — 2024-08-16

COVID19’s medicine are yet undiscovered. Nevertheless, spread prevention are consider greater alternative to secure human life. This research study aim to apply GIS-based mobile in determine the pattern of people movement among Sabah local community. Secondary data of COVID19 are obtained from Ministry of Health, Malaysia, and GIS-based map from Google Earth Desktop. ArcGIS Version 10 software is applied to carry out descriptive and buffering analysis. The result indicates continuous increase in numbers of patients due to COVID19 in year 2021. Buffering analysis shows 5 metre for people who consider having medical condition or older people, while 1 metre for people that are not having any medical condition or not older people. Overlapping buffering will develop alert and notification to both users of GIS mobility based Apps. In conclusion, this technology using ‘Live Tracking System’ Apps could enhance the quality of human life by alert and notify the surrounding condition whenever staying outside of the house. Although scientists and researchers are working so hard to develop the medicine, humanare also have responsible to stop and prevent the COVID19 from being continuously spreading within human being.

Antioxidant And Anticancer Potential of Bioactive Compounds from Locally Isolated Microalgae

Ain Nafiza Basha — 2024-08-16

The current cancer therapy research focuses on the curative strategies but also targeting to improve the development of the preventive strategies. Anticancer, antibacterial, antioxidant, and anti-inflammatory effects have been demonstrated by the bioactive compound extracted from microalgae. Marine organisms, particularly microalgae might be one the alternative that may contribute to the achievement of one of Sustainable Development Goals (SDG) which is SDG 3, Good Health and Wellbeing. It is crucial for long-term sustainable development to ensure healthy lives and promote well-being at all ages. Two microalgal samples from Malaysia Acutodesmus obliquus (CN01) and Desmodesmus perforates (SP04) were isolated from fresh waters and cultivated. A total of three different solvents, polar, intermediate and nonpolar solvent was used to extracts the microalgae sample which are methanol, acetone and hexane, respectively. Acutodesmus obliquus and Desmodesmus perforates extracts show low total phenolic content in range from 0.2447 ± 0.0009 to 0.2614 ± 0.0003. Secondly, the antioxidants activity of both microalgae shows significant radical scavenging activity especially in acetone extracts of both microalgae, with values of 11.5433 ± 0.0115 and 13.5847 ± 0.0618 for Acutodesmus obliquus (CN01) whereas Desmodesmus (SP04), 13.7898 ± 0.2601 and 22.3212 ± 0.2302 scavenging activity percentage. Then, the anticancer effect of the crude extracts was tested against breast cancer, MCF-7 breast cancer cell lines by using MTT assay and apoptosis assay. Methanolic extract has demonstrated high antiproliferative effect against MCF-7, with cell inhibition percentage within range of 87±1.1271 % to 73 ± 0.2744 % and 82 ± 0.0236 % to 73 ± 0.0423 % of Acutodesmus obliquus (CN01) and Desmodesmus (SP04) respectively. Finally, both microalgae show similar compound group as HPLC is used to identified lipid, which is believed to play the big role in contributing to anticancer and antioxidant activity. This suggests that Acutodesmus obliquus sp and Desmodesmus perforates sp possess diverse biosynthetic capacities, potentially enabling the creation of new pharmaceuticals.

Sacrococcygeal Teratoma: Tales of the “Tailbone” Tumour in a Newborn

Tharveen Nair Chandrasekaran — 2024-08-16

Sacrococcygeal teratoma (SCT) is a rare tumour with a low incidence, but it is the most common extragonadal tumour in the newborn. It occurs at the base of the coccyx (tailbone) and is derived from embryonic germ cell layers. Although the majority are benign in nature, they are associated with significant morbidity and mortality for the mother and the foetus. A multidisciplinary approach is needed where an accurate early diagnosis should be made antenatally, leading to anticipation of complications during intrapartum for the mother and foetus, and ultimately early, complete surgical excision of the tumour. The prognosis for survival is good after resection. We report a case of a newborn delivered at 29 weeks who was diagnosed with SCT at post-partum but unfortunately passed away due to the complications of prematurity before surgery could be performed. This case report highlights the literature review of this pathology, especially the management of SCT, which begins in the antenatal period soon after the diagnosis is made.