Synthesis of Trans-4-Hydroxyprolineamide and 3-Ketoproline Ethyl Ester for Green Asymmetric Organocatalysts

Authors

  • Noraishah Abdullah Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
  • Zurina Shaameri Centre for Chemical Synthesis & Polymer Technology, University Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
  • Ahmad Sazali Hamzah Centre for Chemical Synthesis & Polymer Technology, University Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
  • Mohd Fazli Mohammat Centre for Chemical Synthesis & Polymer Technology, University Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

DOI:

https://doi.org/10.37934/araset.38.1.97108

Keywords:

Organocatalysts, Proline, Chiral Prolineamide, Condensation Reaction, Pyrrolidine Ring

Abstract

Organocatalysts have become one of the three pillars in asymmetric reactions, along with metal catalysis and enzyme catalysis. Organocatalysis is widely acknowledged in both academia and industry as a practical and advantageous synthetic method owing to its operational ease, readily available catalyst, environmentally friendly, and minimal toxicity. Much attention has been focused on the organocatalyst for its superior properties as an efficient and clean catalyst. In this work, a series of green organocatalysts of trans-4-hydroxyprolineamide were efficiently obtained in a two-step reaction utilizing EDC.HCl and HOBT as coupling reagents via a condensation reaction. The yield furnished in 93% to 97% yields. These organocatalysts have big potential in asymmetric reactions such as aldol and Michael addition reactions.

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Author Biographies

Noraishah Abdullah, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

noraishah6748@uitm.edu.my

Zurina Shaameri, Centre for Chemical Synthesis & Polymer Technology, University Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

Ahmad Sazali Hamzah, Centre for Chemical Synthesis & Polymer Technology, University Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

Mohd Fazli Mohammat, Centre for Chemical Synthesis & Polymer Technology, University Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

Published

2024-01-25

Issue

Section

Articles

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