Design of PVA/Chitosan Loaded with Chromolaena Odorata Extract as Wound Dressings

Authors

  • Nur ‘Ainun Mokhtar Faculty of Pharmacy, Universiti Teknologi MARA Cawangan Pulau Pinang, Bertam Campus, 13200 Kepala Batas, Pulau Pinang, Malaysia
  • Fatahiya Mohamed Tap School of Chemical Engineering, Faculty of Engineering, Universiti Teknologi MARA Cawangan Terengganu, Bukit Besi Campus, Terengganu, Malaysia
  • Nurul Bahiyah Ahmad Khairudin Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, International Campus, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, Malaysia
  • Roshafima Rasit Ali Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, International Campus, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, Malaysia
  • Siti Zalita Ad Talib Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, International Campus, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, Malaysia

DOI:

https://doi.org/10.37934/araset.30.1.311320

Keywords:

Chromolaena odorata, wound dressing, hydrogel, optimization, PVA/Chitosan, biomaterial

Abstract

This current study was conducted to investigate the optimal fabrication variable that would give desirable properties in designing hydrogel wound dressings. This new PVA/chitosan hydrogel loaded with Chromolaena odorata were fabricated using solvent-casting method. Variables including PVA concentration (3, 5, 7 and 10% w/v), chitosan concentration (1, 2, 3, 4 and 5% w/v) and PVA/Chitosan ratio (10:90, 30:70, 50:50, 70:30 and 90:10) were investigated and elucidated. Hydrogel properties including tensile strength, swelling capacity, erosion rate and porosity were measured and effects of the fabrication variables towards these properties were elucidated. In conclusion, desirable PVA/Chitosan hydrogel loaded with Chromolaena odorata extract as wound dressing was favorly designed. The optimal range for PVA concentration, chitosan concentration and PVA/Chitosan ratio were 5% to 7%, 2% to 3% and 50:50 to 70:30 respectively.

Author Biographies

Nur ‘Ainun Mokhtar, Faculty of Pharmacy, Universiti Teknologi MARA Cawangan Pulau Pinang, Bertam Campus, 13200 Kepala Batas, Pulau Pinang, Malaysia

nurain2942@uitm.edu.my

Fatahiya Mohamed Tap, School of Chemical Engineering, Faculty of Engineering, Universiti Teknologi MARA Cawangan Terengganu, Bukit Besi Campus, Terengganu, Malaysia

fatahiya@uitm.edu.my

Nurul Bahiyah Ahmad Khairudin, Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, International Campus, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, Malaysia

r-bahiah@utm.my

Roshafima Rasit Ali, Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, International Campus, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, Malaysia

roshafima@utm.my

Siti Zalita Ad Talib, Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, International Campus, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, Malaysia

r-zalita@utm.my

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Published

2023-03-30

How to Cite

Nur ‘Ainun Mokhtar, Fatahiya Mohamed Tap, Nurul Bahiyah Ahmad Khairudin, Roshafima Rasit Ali, & Siti Zalita Ad Talib. (2023). Design of PVA/Chitosan Loaded with Chromolaena Odorata Extract as Wound Dressings. Journal of Advanced Research in Applied Sciences and Engineering Technology, 30(1), 311–320. https://doi.org/10.37934/araset.30.1.311320

Issue

Vol. 30 No. 1: March (2023)

Section

Articles

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