Development and In-vitro Evaluation of Konjac Glucomannan/Virgin Coconut Oil Based Asymmetric Membrane for Wound Dressing

Abstract

Asymmetric membranes have promising features for use in wound dressings. A permeable bottom layer absorbs the wound exudate, whereas the occlusive top layer restricts microbiological penetration and avoids an excessive loss of water. Recently, asymmetric membranes made of konjac glucomannan (KGM), a natural polysaccharide, have been explored as potential wound treatments. However, there are no studies reported regarding the incorporation of other materials into KGM asymmetric membrane. Due to its biocompatibility and antimicrobial properties, virgin coconut oil (VCO) is a good choice for promoting the healing process. In this study, we examine the potential of using KGM asymmetric membrane with different concentration of VCO as wound dressing material. The membrane sample's asymmetric morphology and good thermal stability were both revealed by scanning electron microscopy and thermogravimetric studies, respectively. In addition, biological and fluid handling capacity analysis indicated that the KGM-VCO membrane is biocompatible and able to maintain the ideal moist environment for wound healing.