Transport Process of Virus Concentration from Airway to Cerebral Artery by using Computational Fluid Dynamics
DOI:
https://doi.org/10.37934/arnht.28.1.5579Keywords:
Coupled Analysis, Airway, Cerebral Artery, Virus Concentration, Risk Evaluation, CFDAbstract
When a person infected with the virus releases aerosol including the virus by sneezing or talking, the virus stays in atmosphere for a long time. If other persons inhale the virus, the person maybe infected. In our previous researches, in order to decrease efficiently the risk of infection, various indoor ventilation conditions have been evaluated by analyzing transport process of the virus concentration using Computational Fluid Dynamics (CFD). From them, it was found that indoor ventilation condition can be optimised by evaluating amount of the virus concentration and residence time. However, the infection process in air way and vascular when these airborne viruses from indoor air is inhaled has not been elucidated yet. In this research, a couple analysis from nasal cavity to cerebral artery via organ is tried to be applied in order to analyze the transport process of virus concentration from nasal cavity to cerebral artery. In addition, the effect of breathing waveforms and virus proliferation on the virus infection is evaluated. Regarding the methods, 3D CAD model of these three parts is created. Continuity equation, Navier-Stokes equation and transport equations of virus concentration are used as the governing equations. The transport equations in the organ is modified with the virus proliferation. Inlet boundary conditions in the nasal cavity are set up to be four types of breathing waveforms. A boundary condition between the nasal cavity and the organ is continuity of virus concentration at the contact surface. Similarly, the other boundary condition between the organ and the cerebral artery is continuity of virus concentration. As results, it was found that the virus concentration in the cerebral artery in case of sinusoidal breathing waveform with long period is the smallest. It was also found that the virus concentration in the organ and the cerebral artery in case of proliferation within the organ is higher than that has no proliferations. It is concluded that a method for minimalizing risk of virus infection can be proposed by the couple analysis.
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Zhang, Zhihang, Taehoon Han, Kwang Hee Yoo, Jesse Capecelatro, André L. Boehman, and Kevin Maki. "Disease transmission through expiratory aerosols on an urban bus." Physics of Fluids 33, no. 1 (2021). https://doi.org/10.1063/5.0037452 DOI: https://doi.org/10.1063/5.0037452
Kohanski, Michael A., L. James Lo, and Michael S. Waring. "Review of indoor aerosol generation, transport, and control in the context of COVID‐19." In International forum of allergy & rhinology, vol. 10, no. 10, pp. 1173-1179. 2020. https://doi.org/10.1002/alr.22661 DOI: https://doi.org/10.1002/alr.22661
Noorimotlagh, Zahra, Neemat Jaafarzadeh, Susana Silva Martínez, and Seyyed Abbas Mirzaee. "A systematic review of possible airborne transmission of the COVID-19 virus (SARS-CoV-2) in the indoor air environment." Environmental research 193 (2021): 110612. https://doi.org/10.1016/j.envres.2020.110612 DOI: https://doi.org/10.1016/j.envres.2020.110612
Rowe, Bertrand R., André Canosa, Jean-Michel Drouffe, and James Brian Alexander Mitchell. "Simple quantitative assessment of the outdoor versus indoor airborne transmission of viruses and COVID-19." Environmental research 198 (2021): 111189. https://doi.org/10.1016/j.envres.2021.111189 DOI: https://doi.org/10.1016/j.envres.2021.111189
Bazant, Martin Z., Ousmane Kodio, Alexander E. Cohen, Kasim Khan, Zongyu Gu, and John WM Bush. "Monitoring carbon dioxide to quantify the risk of indoor airborne transmission of COVID-19." Flow 1 (2021): E10. https://doi.org/10.1017/flo.2021.10 DOI: https://doi.org/10.1017/flo.2021.10
Wu, Hsiu, Minn M. Soe, Rebecca Konnor, Raymund Dantes, Kathryn Haass, Margaret A. Dudeck, Cindy Gross et al. "Hospital capacities and shortages of healthcare resources among US hospitals during the coronavirus disease 2019 (COVID-19) pandemic, National Healthcare Safety Network (NHSN), March 27–July 14, 2020." Infection Control & Hospital Epidemiology 43, no. 10 (2022): 1473-1476. https://doi.org/10.1017/ice.2021.280 DOI: https://doi.org/10.1017/ice.2021.280
Soyemi, Toluwalashe Sogbenga, and Abdullahi Tunde Aborode. "Shortage of hospital bed capacity and overcrowding in emergency tertiary healthcare centers in Nigeria." Annals of Medicine and Surgery 82 (2022). https://doi.org/10.1016/j.amsu.2022.104675 DOI: https://doi.org/10.1016/j.amsu.2022.104675
Gubler, Duane J. "Dengue and dengue hemorrhagic fever." Clinical microbiology reviews 11, no. 3 (1998): 480-496. https://doi.org/10.1128/CMR.11.3.480 DOI: https://doi.org/10.1128/CMR.11.3.480
Feng, Kaishan, Yoshiki Yanagita, Yuko Miyamura, Adi Azriff Basri, Mohammad Zuber, Siti Rohani, Kamarul Arifin Ahmad, and Masaaki Tamagawa. "CFD Analysis of Indoor Ventilation for Airborne Virus Infection." Journal of Advanced Research in Numerical Heat Transfer 14, no. 1 (2023): 1-16. https://doi.org/10.37934/arnht.14.1.116 DOI: https://doi.org/10.37934/arnht.14.1.116
Kaishan, Feng, Yanagita Yoshiki, Miyamura Yuko, Basri Adi Azriff, Zuber Mohammad, Rohani Siti, Aziz Abdul, Ahmad Kamarul Arifin, and Tamagawa Masaaki. "Fundamental Investigation on Ventilation Methods of Indoor Air for Preventing Infections by Computational Fluid Dynamics Analysis." ICIC Express Letters 17, no. 10 (2023): 1103. https://doi.org/10.24507/icicel.17.10.1103
Dai, Hui, and Bin Zhao. "Association of the infection probability of COVID-19 with ventilation rates in confined spaces." In Building simulation, vol. 13, pp. 1321-1327. Tsinghua University Press, 2020. https://doi.org/10.1007/s12273-020-0703-5 DOI: https://doi.org/10.1007/s12273-020-0703-5
Eames, Ian, J. W. Tang, Y. Li, and P. Wilson. "Airborne transmission of disease in hospitals." Journal of the Royal Society Interface 6, no. suppl_6 (2009): S697-S702. https://doi.org/10.1098/rsif.2009.0407.focus DOI: https://doi.org/10.1098/rsif.2009.0407.focus
Liu, Li, Yuguo Li, Peter Vilhelm Nielsen, Jianjian Wei, and Rasmus Lund Jensen. "Short‐range airborne transmission of expiratory droplets between two people." Indoor air 27, no. 2 (2017): 452-462. https://doi.org/10.1111/ina.12314 DOI: https://doi.org/10.1111/ina.12314
Kassem, Fatma AbdelMordy. AbdelGawad, Ahmed Farouk. Abuel-Ezz, Ali Elsayed. Nassief, Mofreh Melad. Adel, Mohamed. “Design and Performance Evaluation of a Portable Chamber for Prevention of Aerosol Airborne –Infection.” Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 100, issue 2 (2022): 181-197. https://doi.org/10.37934/arfmts.100.2.181197 DOI: https://doi.org/10.37934/arfmts.100.2.181197
El-Haroun, Ahmed Fahmy. Kaseb, Sayed Ahmed. Fouad, Mahmoud Ahmed. Kayed, Hatem Omar. “Numerical Investigation of Covid-19 Infection Spread Expelled fromCough in an Isolation Ward Under Different Air Distribution Strategies.” Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 95, issue 1 (2022): 17-35. https://doi.org/10.37934/arfmts.95.1.1735 DOI: https://doi.org/10.37934/arfmts.95.1.1735
Yanagita, Yoshiki. Feng, Kaishan. Miyamura, Yuko. Basri, Adi Azriff. Zuber, Mohammd. Rohani, Siti. Aziz, Abdul. Ahmad, Kamarul Arifin. Tamagawa, Masaaki. “Evaluation of Virus Concentration Analysis in the Airway by CFD.” Journal of Advanced Research in Numerical Heat Transfer 13, no. 1 (2023): 96-105. https://doi.org/10.37934/arnht.13.1.96105 DOI: https://doi.org/10.37934/arnht.13.1.96105
Farnoud, Ali, Ingo Baumann, Mohammad Mehdi Rashidi, Otmar Schmid, and Eva Gutheil. "Simulation of patient-specific bi-directional pulsating nasal aerosol dispersion and deposition with clockwise 45 and 90 nosepieces." Computers in Biology and Medicine 123 (2020): 103816. https://doi.org/10.1016/j.compbiomed.2020.103816 DOI: https://doi.org/10.1016/j.compbiomed.2020.103816
Li, Chengyu. Jiang, Jianbo. Dong, Haibo. Zhao, Kai. “Computational modeling and validation of human nasal airflow under various breathing conditions.” Journal of Biomechanics 64, no.7 (2017): 59-68. https://doi.org/10.1016/j.jbiomech.2017.08.031 DOI: https://doi.org/10.1016/j.jbiomech.2017.08.031
Zhao, Kai, Pamela Dalton, Geoffery C. Yang, and Peter W. Scherer. "Numerical modeling of turbulent and laminar airflow and odorant transport during sniffing in the human and rat nose." Chemical senses 31, no. 2 (2006): 107-118. https://doi.org/10.1093/chemse/bjj008 DOI: https://doi.org/10.1093/chemse/bjj008
Inthavong, Kiao, Jiawei Ma, Yidan Shang, Jingliang Dong, Annicka SR Chetty, Jiyuan Tu, and Dennis Frank-Ito. "Geometry and airflow dynamics analysis in the nasal cavity during inhalation." Clinical Biomechanics 66 (2019): 97-106. https://doi.org/10.1016/j.clinbiomech.2017.10.006 DOI: https://doi.org/10.1016/j.clinbiomech.2017.10.006
Brüning, Jan, Thomas Hildebrandt, Werner Heppt, Nora Schmidt, Hans Lamecker, Angelika Szengel, Natalja Amiridze et al. "Characterization of the airflow within an average geometry of the healthy human nasal cavity." Scientific reports 10, no. 1 (2020): 3755. https://doi.org/10.1038/s41598-020-60755-3 DOI: https://doi.org/10.1038/s41598-020-60755-3
Yu, Shen. Wang, Danqing. Guo, Yan. Shen, Shuang. Wang, Jizhe. “Numerical Study on the Distribution of Nitric Oxide Concentration in the Nasal Cavity of Healthy People during Breathing.” Nitric Oxide 130 (2023): 12–21. https://doi.org/10.1016/j.niox.2022.11.002 DOI: https://doi.org/10.1016/j.niox.2022.11.002
Corda, John Valerian, B. Satish Shenoy, Leslie Lewis, Prakashini K, SM Abdul Khader, Kamarul Arifin Ahmad, and Mohammad Zuber. "Nasal airflow patterns in a patient with septal deviation and comparison with a healthy nasal cavity using computational fluid dynamics." Frontiers in Mechanical Engineering 8 (2022): 1009640. https://doi.org/10.3389/fmech.2022.1009640 DOI: https://doi.org/10.3389/fmech.2022.1009640
Zuber, Mohammad, Kamarul Arifin Ahmad, SM Abdul Khader, R. Balakrishnan, Sharath Honnani, Sana Althaf Hussain, and A. B. V. Barboza. "Effect of Septum Deviation on the Airflow Distribution for a Patient Specific Model using Numerical Methods." Journal of Advanced Research in Numerical Heat Transfer 14, no. 1 (2023): 49-57. https://doi.org/10.37934/arnht.14.1.4957 DOI: https://doi.org/10.37934/arnht.14.1.4957
Gras-Cabrerizo, Juan R., Elena García-Garrigós, Joan R. Montserrat-Gili, Juan R. Gras-Albert, Rosa Mirapeix-Lucas, Humbert Massegur-Solench, and Miquel Quer-Agusti. "Anatomical correlation between nasal vascularisation and the design of the endonasal pedicle flaps." Indian Journal of Otolaryngology and Head & Neck Surgery 70 (2018): 167-173. https://doi.org/10.1007/s12070-017-1197-z DOI: https://doi.org/10.1007/s12070-017-1197-z
Meulemans, A., F. Paycha, P. Hannoun, and M. Vulpillat. "Measurement and clinical and pharmacokinetic implications of diffusion coefficients of antibiotics in tissues." Antimicrobial agents and chemotherapy 33, no. 8 (1989): 1286-1290. https://doi.org/10.1128/AAC.33.8.1286 DOI: https://doi.org/10.1128/AAC.33.8.1286
Yushkevich, Paul A., Joseph Piven, Heather Cody Hazlett, Rachel Gimpel Smith, Sean Ho, James C. Gee, and Guido Gerig. "User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability." Neuroimage 31, no. 3 (2006): 1116-1128. https://doi.org/10.1016/j.neuroimage.2006.01.015 DOI: https://doi.org/10.1016/j.neuroimage.2006.01.015
Bullitt, Elizabeth, Donglin Zeng, Guido Gerig, Stephen Aylward, Sarang Joshi, J. Keith Smith, Weili Lin, and Matthew G. Ewend. "Vessel tortuosity and brain tumor malignancy: a blinded study1." Academic radiology 12, no. 10 (2005): 1232-1240. https://doi.org/10.1016/j.acra.2005.05.027 DOI: https://doi.org/10.1016/j.acra.2005.05.027
Kousaka, Yasuo. Nomura, Toshiyuki. Naito, Makio. “The Possibility of the Aerosol Infection of Corona Disease COVID-19 -Analysis from the Viewpoint of Particle Technology-.” Journal of the Society of Powder Technology 57 (2020): 526-529. https://doi.org/10.4164/sptj.57.526 DOI: https://doi.org/10.4164/sptj.57.526
White, Nathan, John-David Seelig, and Sudarshan K. Loyalka. "Computation of drag and diffusion coefficient for coronavirus: I." Journal of Aerosol Science 157 (2021): 105806. https://doi.org/10.1016/j.jaerosci.2021.105806 DOI: https://doi.org/10.1016/j.jaerosci.2021.105806
Nunes-Correia, Isabel, Joao Ramalho-Santos, Shlomo Nir, and Maria C. Pedroso de Lima. "Interactions of influenza virus with cultured cells: detailed kinetic modeling of binding and endocytosis." Biochemistry 38, no. 3 (1999): 1095-1101. https://doi.org/10.1021/bi9812524 DOI: https://doi.org/10.1021/bi9812524
Figueroa, C. Alberto, Irene E. Vignon-Clementel, Kenneth E. Jansen, Thomas JR Hughes, and Charles A. Taylor. "A coupled momentum method for modeling blood flow in three-dimensional deformable arteries." Computer methods in applied mechanics and engineering 195, no. 41-43 (2006): 5685-5706. https://doi.org/10.1016/j.cma.2005.11.011 DOI: https://doi.org/10.1016/j.cma.2005.11.011
Gabriel, Gülsah, Karin Klingel, Anna Otte, Swantje Thiele, Ben Hudjetz, Gökhan Arman-Kalcek, Martina Sauter et al. "Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus." Nature communications 2, no. 1 (2011): 156. https://doi.org/10.1038/ncomms1158 DOI: https://doi.org/10.1038/ncomms1158
Kandeil, Ahmed, Christopher Patton, Jeremy C. Jones, Trushar Jeevan, Walter N. Harrington, Sanja Trifkovic, Jon P. Seiler et al. "Rapid evolution of A (H5N1) influenza viruses after intercontinental spread to North America." Nature communications 14, no. 1 (2023): 3082. https://doi.org/10.1038/s41467-023-38415-7 DOI: https://doi.org/10.1038/s41467-023-38415-7
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