Hemodynamic and Flow Recirculation Effect on Rupture  Prediction of Middle Cerebral Artery Aneurysm

Nadia Shaira Shafii; Ryuhei Yamaguchi; Ahmad Zahran Md Khudzari; Gaku Tanaka; Atsushi  Saitoh; Makoto Ohta; Kahar Osman

Authors

Nadia Shaira Shafii School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia
Ryuhei Yamaguchi Institute of Fluid Science, Tohoku University, Miyagi, Japan
Ahmad Zahran Md Khudzari IJN-UTM Cardiovascular Engineering Center, Universiti Teknologi Malaysia, Johor Bahru, Malaysia
Gaku Tanaka Graduate School of Engineering, Chiba University, Chiba, Japan
Atsushi Saitoh Department of Neurosurgery, Sendai Medical Center, Miyagi, Japan
Makoto Ohta Institute of Fluid Science, Tohoku University, Miyagi, Japan
Kahar Osman School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia

Keywords:

Cerebral Aneurysm, Pulsatile Flow, Flow Recirculation, Particle Image Velocimetry, Computational Fluid Dynamics

Abstract

The mortality and morbidity rate due to the severe effect of intracranial aneurysm (IA) is increasing, which has driven research trend on aneurysm rupture risk. By understanding the nature and causes of the aneurysm rupture, preventive measures could be taken in avoiding rupture besides recommending proper treatments such as endovascular coiling. However, the presence of flow recirculation causes the aneurysm wall to degenerate and weakened. The weakened wall is due to the haemodynamic factors such as velocity, wall shear stress (WSS), time average WSS (TAWSS), OSI and RRT, which were analysed in this study. In the present study, the flow model simulated a human patient-specific aneurysm at the apex of the bifurcation in the middle cerebral artery (MCA) in the transient state. Experimental results of full-scale models were collected on a median, side plane to study the flow behaviour and validation to the numerical simulation settings, which resulted in good agreement with only 8% difference. The simulation results obtained showed several interesting findings. The jet flow into the aneurysm led to complex vortex formation due to impinging flow behaviour within the aneurysm dome. Additionally, the area that recorded low velocity was at 30% of low TAWSS with only 1% of OSI that was more than 0.3, while the OSI critical value and 0.27% area exceeded RRT threshold, which caused the large oscillating blood flow direction and activated the atherosclerosis progression. These results suggest that the jet flow into the dome may cause further damage to the wall of the MCA aneurysm, which will help in providing an insight towards completing a guidance system assessment of rupture risk for medical practitioners in future work.