Study of Nanoparticle Diffusion in Capillary-Tissue Exchange System using Jeffrey Nanofluid Model: Effects of Shapes of Nanoparticles

Authors

  • Rekha Bali Department Of Mathematics, School of Basic & Applied Sciences, Harcourt Butler Technical University, Kanpur- 208002, U.P., India
  • Bhawini Prasad Department Of Mathematics, School of Basic & Applied Sciences, Harcourt Butler Technical University, Kanpur- 208002, U.P., India

DOI:

https://doi.org/10.37934/cfdl.15.6.130153

Keywords:

Diffusion, Jeffrey Nanofluid, Taylor’s dispersion model

Abstract

The present work concerns the diffusion of nanoparticles in capillary-tissue exchange system. Nanoparticle are inoculated into the patient’s body by intertumoral administration. Thus, nanoparticles diffuse into tumoral tissues through diseased capillary walls. Blood in the capillaries is modelled as Jeffrey fluid. The resultant fluid is called Jeffrey nanofluid. In this model we have described diffusion occurring through the capillary walls into the surrounding tissue. The mathematical results are obtained analytically and have been compared with numerical solution. Graphs have been plotted using MATLAB. The effects of shape factor of nanoparticles, volume fraction of nanoparticles, Jeffrey fluid parameter, viscosity index and viscosity parameter has been observed on velocity and concentration of nanoparticles diffusing into the tissues. A noticeable observation states that brick shaped nanoparticles diffuse most rapidly i.e., have higher diffusion rates than other shapes

Author Biographies

Rekha Bali, Department Of Mathematics, School of Basic & Applied Sciences, Harcourt Butler Technical University, Kanpur- 208002, U.P., India

dr.rekhabali1964@gmail.com

Bhawini Prasad, Department Of Mathematics, School of Basic & Applied Sciences, Harcourt Butler Technical University, Kanpur- 208002, U.P., India

jayabhawini@gmail.com

References

Qiu, Xianjie. Fluid flow in a Krogh cylinder: A model for a single capillary and surrounding tissue. Missouri University of Science and Technology, 2018.

Chauhan, Satyendra Singh, and Ashish Tiwari. "Solute dispersion in non-Newtonian fluids flow through small blood vessels: A varying viscosity approach." European Journal of Mechanics-B/Fluids 94 (2022): 200-211. https://doi.org/10.1016/j.euromechflu.2022.02.009

Tandon, P. N., and R. Agarwal. "A study of diffusion is modelled in normal and stenotic capillary tissue exchange system." In Proc. Int. Conf. on Computational Methods in Flow Analysis, vol. 2, p. 1154. 1988.

Bali, Rekha, Bhawini Prasad, and Swati Mishra. “A Review on Mathematical Models for Nanoparticle Delivery in the Blood.” International Journal of Advanced Research 10, no. 04 (2022): 130–46. https://doi.org/10.21474/IJAR01/14526

Qiu, Lin, Ning Zhu, Yanhui Feng, Efstathios E. Michaelides, Gaweł Żyła, Dengwei Jing, Xinxin Zhang, Pamela M. Norris, Christos N. Markides, and Omid Mahian. "A review of recent advances in thermophysical properties at the nanoscale: From solid state to colloids." Physics Reports 843 (2020): 1-81. https://doi.org/10.1016/j.physrep.2019.12.001

Simpson, Sarah, Austin Schelfhout, Chris Golden, and Saeid Vafaei. "Nanofluid thermal conductivity and effective parameters." Applied Sciences 9, no. 1 (2018): 87. https://doi.org/10.3390/app9010087

Deng, Yudi, Xudong Zhang, Haibin Shen, Qiangnan He, Zijian Wu, Wenzhen Liao, and Miaomiao Yuan. "Application of the nano-drug delivery system in treatment of cardiovascular diseases." Frontiers in bioengineering and biotechnology 7 (2020): 489. https://doi.org/10.3389/fbioe.2019.00489

Kwatra, S. "Nanotechnology and medicine—The upside and the downside." IJDDR 5 (2013): 0975-9344.

Gonçalves, Inês, Reinaldo Souza, Gonçalo Coutinho, João Miranda, Ana Moita, José Eduardo Pereira, António Moreira, and Rui Lima. "Thermal conductivity of nanofluids: a review on prediction models, controversies and challenges." Applied Sciences 11, no. 6 (2021): 2525. https://doi.org/10.3390/app11062525

Moghaddam, Hossein Asadi, Ashkan Ghafouri, and Reza Faridi Khouzestani. "Viscosity and thermal conductivity correlations for various nanofluids based on different temperature and nanoparticle diameter." Journal of the Brazilian Society of Mechanical Sciences and Engineering 43, no. 6 (2021): 303. https://doi.org/10.1007/s40430-021-03017-1

Ellahi, R., S. U. Rahman, and S. Nadeem. "Blood flow of Jeffrey fluid in a catherized tapered artery with the suspension of nanoparticles." Physics Letters A 378, no. 40 (2014): 2973-2980. https://doi.org/10.1016/j.physleta.2014.08.002

Rahman, S. U., R. Ellahi, Sohail Nadeem, and QM Zaigham Zia. "Simultaneous effects of nanoparticles and slip on Jeffrey fluid through tapered artery with mild stenosis." Journal of Molecular liquids 218 (2016): 484-493. https://doi.org/10.1016/j.molliq.2016.02.080

Krogh, August. "The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue." The Journal of physiology 52, no. 6 (1919): 409-415. https://doi.org/10.1113/jphysiol.1919.sp001839

Popel, Aleksander S. "Analysis of capillary-tissue diffusion in multicapillary systems." Mathematical biosciences 39, no. 3-4 (1978): 187-211. https://doi.org/10.1016/0025-5564(78)90053-6

Blum, Jacob J. "Concentration profiles in and around capillaries." American Journal of Physiology-Legacy Content 198, no. 5 (1960): 991-998. https://doi.org/10.1152/ajplegacy.1960.198.5.991

Levitt, David G. "Theoretical model of capillary exchange incorporating interactions between capillaries." American Journal of Physiology-Legacy Content 220, no. 1 (1971): 250-255. https://doi.org/10.1152/ajplegacy.1971.220.1.250

Tandon, P. N., J. K. Misra, and R. L. Verma. "Peripheral-layer viscosity and microstructural effects on the capillary-tissue fluid exchange." Mathematical Biosciences 62, no. 1 (1982): 7-22. https://doi.org/10.1016/0025-5564(82)90060-8

Siddiqui, S. U., and Shailesh Mishra. "A study of modified Casson’s fluid in modelled normal and stenotic capillary-tissue diffusion phenomena." Applied mathematics and computation 189, no. 2 (2007): 1048-1057. https://doi.org/10.1016/j.amc.2006.11.151

Singh, Sapna. "Numerical modeling for the modified power law fluid in stenotic capillary-tissue diffusion phenomena'." Archives of Applied Science Research 2, no. 1 (2010): 106.

Bali, Rekha, Swati Mishra, and Mamta Mishra. "Effect of Deformation of Red Cell on Nutritional Transport in Capillary-Tissue Exchange System." Applied Mathematics 2, no. 11 (2011): 1417-1423. https://doi.org/10.4236/am.2011.211200

Ismaeel, A. M., M. A. Mansour, F. S. Ibrahim, and F. M. Hady. "Numerical simulation for nanofluid extravasation from a vertical segment of a cylindrical vessel into the surrounding tissue at the microscale." Applied Mathematics and Computation 417 (2022): 126758. https://doi.org/10.1016/j.amc.2021.126758

Mun, Ellina A., Claire Hannell, Sarah E. Rogers, Patrick Hole, Adrian C. Williams, and Vitaliy V. Khutoryanskiy. "On the role of specific interactions in the diffusion of nanoparticles in aqueous polymer solutions." Langmuir 30, no. 1 (2014): 308-317. https://doi.org/10.1021/la4029035

Madhura, K. R., Babitha Atiwali, and S. S. Iyengar. "Influence of nanoparticle shapes on natural convection flow with heat and mass transfer rates of nanofluids with fractional derivative." Mathematical Methods in the Applied Sciences (2021). https://doi.org/10.1002/mma.7404

Lee, Benjamin J., Yahya Cheema, Shahed Bader, and Gregg A. Duncan. "Shaping nanoparticle diffusion through biological barriers to drug delivery." JCIS Open 4 (2021): 100025. https://doi.org/10.1016/j.jciso.2021.100025

Timofeeva, Elena V., Jules L. Routbort, and Dileep Singh. "Particle shape effects on thermophysical properties of alumina nanofluids." Journal of applied physics 106, no. 1 (2009): 014304. https://doi.org/10.1063/1.3155999

Ijaz, S., and S. Nadeem. "Examination of nanoparticles as a drug carrier on blood flow through catheterized composite stenosed artery with permeable walls." Computer methods and programs in biomedicine 133 (2016): 83-94. https://doi.org/10.1016/j.cmpb.2016.05.004

Ali, Farhad, Saqib Murtaza, Ilyas Khan, Nadeem Ahmad Sheikh, and Kottakkaran Sooppy Nisar. "Atangana–Baleanu fractional model for the flow of Jeffrey nanofluid with diffusion-thermo effects: applications in engine oil." Advances in Difference Equations 2019, no. 1 (2019): 1-21. https://doi.org/10.1186/s13662-019-2222-1

Kotnurkar, Asha S., and Vijaylaxmi T. Talawar. "Influence of Jeffrey nanofluid on peristaltic motion in an inclined endoscope." Computational Engineering and Physical Modeling 4, no. 2 (2021): 68-94.

Hayat, Tasawar, Sajid Qayyum, and Ahmed Alsaedi. "Mechanisms of nonlinear convective flow of Jeffrey nanofluid due to nonlinear radially stretching sheet with convective conditions and magnetic field." Results in physics 7 (2017): 2341-2351. https://doi.org/10.1016/j.rinp.2017.06.052

Shahzad, Faisal, Dumitru Baleanu, Wasim Jamshed, Kottakkaran Sooppy Nisar, Mohamed R. Eid, Rabia Safdar, and Khadiga Ahmed Ismail. "Flow and heat transport phenomenon for dynamics of Jeffrey nanofluid past stretchable sheet subject to Lorentz force and dissipation effects." Scientific Reports 11, no. 1 (2021): 22924. https://doi.org/10.1038/s41598-021-02212-3

Nguyen, T. V., and Ralph E. White. "A finite difference procedure for solving coupled, nonlinear elliptic partial differential equations." Computers & chemical engineering 11, no. 5 (1987): 543-546. https://doi.org/10.1016/0098-1354(87)80029-7

Barua, Sutapa, and Samir Mitragotri. "Challenges associated with penetration of nanoparticles across cell and tissue barriers: a review of current status and future prospects." Nano today 9, no. 2 (2014): 223-243. https://doi.org/10.1016/j.nantod.2014.04.008

Ramana Reddy, J. V., and D. Srikanth. "Impact of blood vessel wall flexibility on the temperature and concentration dispersion." Journal of Applied and Computational Mechanics 6, no. 3 (2020): 564-581.

Tan, Jian Hong, Toru Yamada, Yutaka Asako, Lit Ken Tan, and Nor Azwadi Che Sidik. "Study of Self Diffusion of Nanoparticle Using Dissipative Particle Dynamics." Journal of Advanced Research in Numerical Heat Transfer 10, no. 1 (2022): 1-7.

Shit, G. C., M. Roy, and A. Sinha. "Mathematical modelling of blood flow through a tapered overlapping stenosed artery with variable viscosity." Applied Bionics and Biomechanics 11, no. 4 (2014): 185-195. https://doi.org/10.1155/2014/698750

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Published

2023-04-20

How to Cite

Bali, R. ., & Prasad, B. (2023). Study of Nanoparticle Diffusion in Capillary-Tissue Exchange System using Jeffrey Nanofluid Model: Effects of Shapes of Nanoparticles. CFD Letters, 15(6), 130–153. https://doi.org/10.37934/cfdl.15.6.130153

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