Analysis of Blood Flow in Human Brain Vessels for Newtonian and Non-Newtonian Blood Properties
DOI:
https://doi.org/10.37934/cfdl.15.9.4555Keywords:
Brain MRI, Vertebral-basilar artery, non-Newtonian bloodAbstract
The cerebral artery system can be affected by various diseases such as stroke, carotid stenosis, vertebral stenosis, intracranial stenosis, aneurysms, and vascular malformations. Understanding the blood flow specific to each patient's cerebral arteries can provide crucial information about how these diseases progress and guide potential treatment options. A patient-specific Magnetic Resonance Imaging (MRI) scan of a human brain was utilized to create a 3D model of the arterial system. Blood flow simulations were conducted using the ANSYS (Fluent) R2021 software package. The ICEM meshing tool within the ANSYS software was employed to prepare the models. The velocity rise and pressure drop were observed in the branching of the basilar artery. This can provide valuable patient specific information on various cerebral diseases, and drug delivery cases. The non-Newtonian properties of blood were established by inputting the Power Law parameters into the ANSYS Fluent system. It was observed that the effects of non-Newtonian properties of blood are relatively negligible for the large vessels studied (> 200 um).
References
Mahrous, Samar Ahmed, Nor Azwadi Che Sidik, and Khalid Mansour Saqr. "Investigation of Newtonian and Power-Law Blood Flow Models in a 180 Curved Pipe at Low to Medium Shear Rate." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 69, no. 1 (2020): 148-162. https://doi.org/10.37934/arfmts.69.1.148162
Ramdan, Salman Aslam, Mohammad Rasidi Rasani, Thinesh Subramaniam, Ahmad Sobri Muda, Ahmad Fazli Abdul Aziz, Tuan Mohammad Yusoff Shah Tuan Ya, Hazim Moria, Mohd Faizal Mat Tahir, and Mohd Zaki Nuawi. "Blood Flow Acoustics in Carotid Artery." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 94, no. 1 (2022): 28-44. https://doi.org/10.37934/arfmts.94.1.2844
Ningappa, Abhilash Hebbandi, Suraj Patil, Gowrava Shenoy Belur, Augustine Benjamin Valerian Barboza, Nitesh Kumar, Raghuvir Pai Ballambat, Adi Azriff Basri, Shah Mohammed Abdul Khader, and Masaaki Tamagawa. "Influence of altered pressures on flow dynamics in carotid bifurcation system using numerical methods." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 97, no. 1 (2022): 47-61. https://doi.org/10.37934/arfmts.97.1.4761
Zin, Ahmad Faiz Mat, Ishkrizat Taib, Muhammad Hanafi Asril Rajo Mantari, Bukhari Manshoor, Ahmad Mubarak Tajul Arifin, Mahmod Abd Hakim Mohamad, Muhammad Sufi Roslan, and Muhammad Rafiuddin Azman. "Temperature Variation with Hemodynamic Effect Simulation on Wall Shear Stress in Fusiform Cerebral Aneurysm." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 95, no. 2 (2022): 40-54.
Zain, Norliza Mohd, Zuhaila Ismail, and Peter Johnston. "A Stabilized Finite Element Formulation of Non-Newtonian Fluid Model of Blood Flow in A Bifurcated Channel with Overlapping Stenosis." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 88, no. 1 (2021): 126-139. https://doi.org/10.37934/arfmts.88.1.126139
Chen, Aolin, Adi Azriff Basri, Norzian Ismail, Di Zhu, and Kamarul Arifin Ahmad. "Numerical Study of Subaortic Stenosis and Pannus Formation on Blood Flow Around Mechanical Heart Valves." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 95, no. 2 (2022): 180-190.
Zakaria, Mohamad Shukri, Siti Hajar Zainudin, Haslina Abdullah, Cheng See Yuan, Mohd Juzaila Abd Latif, and Kahar Osman. "CFD Simulation of Non-Newtonian Effect on Hemodynamics Characteristics of Blood Flow through Benchmark Nozzle." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 64, no. 1 (2019): 117-125.
Imtiaz, Nayeem, William A. Stoddard, Arthur T. Johnson, Corrine R. Amato, Jared A. Carter, James A. Roussie, and Steven W. Day. "PULM7: Development of a Miniaturized ECMO Device on a Microfluidic Platform." ASAIO Journal 68, no. Supplement 2 (2022): 87. https://doi.org/10.1097/01.mat.0000841196.95976.61
Hegde, Pranav, SM Abdul Khader, Raghuvir Pai, Masaaki Tamagawa, Ravindra Prabhu, Nitesh Kumar, and Kamarul Arifin Ahmad. "CFD Analysis on Effect of Angulation in A Healthy Abdominal Aorta-Renal Artery Junction." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 88, no. 1 (2021): 149-165. https://doi.org/10.37934/arfmts.88.1.149165
Zain, Norliza Mohd, and Zuhaila Ismail. "Dynamic Response of Heat Transfer in Magnetohydrodynamic Blood Flow Through a Porous Bifurcated Artery with Overlapping Stenosis." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 101, no. 1 (2023): 215-235. https://doi.org/10.37934/arfmts.101.1.215235
Wahyudi, Slamet, Nanda Raihan Vardiansyah, and Putu Hadi Setyorini. "Effect of Blood Perfusion on Temperature Distribution in the Multilayer of the Human Body with Interstitial Hyperthermia Treatment for Tumour Therapy." CFD Letters 14, no. 6 (2022): 102-114. https://doi.org/10.37934/cfdl.14.6.102114
Zain, Norliza Mohd, Zuhaila Ismail, and Peter Johnston. "Numerical Analysis of Blood Flow Behaviour in a Constricted Porous Bifurcated Artery under the Influence of Magnetic Field." CFD Letters 15, no. 1 (2023): 39-58. https://doi.org/10.37934/cfdl.15.1.3958
Saufi, Ommar Mykael Mat, Nur Amani Hanis Binti Roseman, Ishkrizat Taib, Nurul Fitriah Nasir, Ahmad Mubarak Tajul Ariffin, Nor Adrian Nor Salim, Shahrul Azmir Osman, Nofrizal Idris Darlis, and Ali Kamil Kareem. "Flow Characteristics on Carotid Artery Bifurcation of Different Aneurysmal Morphology." CFD Letters 15, no. 2 (2023): 25-40. https://doi.org/10.37934/cfdl.15.2.2540
Alastruey, Jordi, Nan Xiao, Henry Fok, Tobias Schaeffter, and C. Alberto Figueroa. "On the impact of modelling assumptions in multi-scale, subject-specific models of aortic haemodynamics." Journal of The Royal Society Interface 13, no. 119 (2016): 20160073. https://doi.org/10.1098/rsif.2016.0073
Lopes, D., Hélder Puga, J. Carlos Teixeira, and S. F. Teixeira. "Influence of arterial mechanical properties on carotid blood flow: Comparison of CFD and FSI studies." International Journal of Mechanical Sciences 160 (2019): 209-218. https://doi.org/10.1016/j.ijmecsci.2019.06.029
Jin, Zan-Hui, M. Barzegar Gerdroodbary, P. Valipour, M. Faraji, and Nidal H. Abu-Hamdeh. "CFD investigations of the blood hemodynamic inside internal cerebral aneurysm (ICA) in the existence of coiling embolism." Alexandria Engineering Journal 66 (2023): 797-809. https://doi.org/10.1016/j.aej.2022.10.070
Lee, Robert MKW. "Morphology of cerebral arteries." Pharmacology & therapeutics 66, no. 1 (1995): 149-173. https://doi.org/10.1016/0163-7258(94)00071-A
Portegies, M. L. P., P. J. Koudstaal, and M. A. Ikram. "Cerebrovascular disease." Handbook of clinical neurology 138 (2016): 239-261. https://doi.org/10.1016/B978-0-12-802973-2.00014-8
Mittal, Rajat, Jung Hee Seo, Vijay Vedula, Young J. Choi, Hang Liu, H. Howie Huang, Saurabh Jain, Laurent Younes, Theodore Abraham, and Richard T. George. "Computational modeling of cardiac hemodynamics: Current status and future outlook." Journal of Computational Physics 305 (2016): 1065-1082. https://doi.org/10.1016/j.jcp.2015.11.022
Gharahi, Hamidreza, Byron A. Zambrano, David C. Zhu, J. Kevin DeMarco, and Seungik Baek. "Computational fluid dynamic simulation of human carotid artery bifurcation based on anatomy and volumetric blood flow rate measured with magnetic resonance imaging." International journal of advances in engineering sciences and applied mathematics 8 (2016): 46-60. https://doi.org/10.1007/s12572-016-0161-6
Priyadharsini, M. "Mathematical modelling and analysis of thermoregulation effects on blood viscosity under magnetic effects and thermal radiation in a permeable stretching capillary." Journal of Thermal Biology 111 (2023): 103398. https://doi.org/10.1016/j.jtherbio.2022.103398
Chandran, Krishna, Indranil Saha Dalal, Kazuya Tatsumi, and Krishnamurthy Muralidhar. "Numerical simulation of blood flow modeled as a fluid-particulate mixture." Journal of Non-Newtonian Fluid Mechanics 285 (2020): 104383. https://doi.org/10.1016/j.jnnfm.2020.104383
Liu, Haipeng, Linfang Lan, Jill Abrigo, Hing Lung Ip, Yannie Soo, Dingchang Zheng, Ka Sing Wong et al. "Comparison of Newtonian and non-Newtonian fluid models in blood flow simulation in patients with intracranial arterial stenosis." Frontiers in physiology 12 (2021): 718540. https://doi.org/10.3389/fphys.2021.782647
Chan, Weng Yew, Yan Ding, and J. Y. Tu. "Modeling of non-Newtonian blood flow through a stenosed artery incorporating fluid-structure interaction." Anziam Journal 47 (2005): C507-C523. https://doi.org/10.21914/anziamj.v47i0.1059
Mohd Adib, Mohd Azrul Hisham, Satoshi Ii, Yoshiyuki Watanabe, and Shigeo Wada. "Minimizing the blood velocity differences between phase-contrast magnetic resonance imaging and computational fluid dynamics simulation in cerebral arteries and aneurysms." Medical & biological engineering & computing 55 (2017): 1605-1619. https://doi.org/10.1007/s11517-017-1617-y
Liu, Jia, Zhengzheng Yan, Yuehua Pu, Wen-Shin Shiu, Jianhuang Wu, Rongliang Chen, Xinyi Leng et al. "Functional assessment of cerebral artery stenosis: a pilot study based on computational fluid dynamics." Journal of Cerebral Blood Flow & Metabolism 37, no. 7 (2017): 2567-2576. https://doi.org/10.1177/0271678X16671321
Jamali, Muhammad Sabaruddin Ahmad, Zuhaila Ismail, and Norsarahaida Saidina Amin. "Effect of Different Types of Stenosis on Generalized Power Law Model of Blood Flow in a Bifurcated Artery." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 87, no. 3 (2021): 172-183. https://doi.org/10.37934/arfmts.87.3.172183
Bodnár, Tomás, Adélia Sequeira, and M. Prosi. "On the shear-thinning and viscoelastic effects of blood flow under various flow rates." Applied Mathematics and Computation 217, no. 11 (2011): 5055-5067. https://doi.org/10.1016/j.amc.2010.07.054
Lanotte, Luca, Johannes Mauer, Simon Mendez, Dmitry A. Fedosov, Jean-Marc Fromental, Viviana Claveria, Franck Nicoud, Gerhard Gompper, and Manouk Abkarian. "Red cells’ dynamic morphologies govern blood shear thinning under microcirculatory flow conditions." Proceedings of the National Academy of Sciences 113, no. 47 (2016): 13289-13294. https://doi.org/10.1073/pnas.1608074113
Anand, M., and K. R. Rajagopal. "A shear-thinning viscoelastic fluid model for describing the flow of blood." International Journal of Cardiovascular Medicine and Science 4, no. 2 (2004): 59-68.
Flanagan, Michael F. "The role of the craniocervical junction in craniospinal hydrodynamics and neurodegenerative conditions." Neurology Research International 2015 (2015). https://doi.org/10.1155/2015/794829
Muiruri, Patrick Irungu, and Oboetswe Seraga Motsamai. "Three Dimensional CFD Simulations of A Wind Turbine Blade Section; Validation." Journal of Engineering Science & Technology Review 11, no. 1 (2018). https://doi.org/10.25103/jestr.111.16
Manual, U. D. F. "ANSYS FLUENT 12.0." Theory Guide (2009): 67.
Siesjö, Bo K. "Cerebral circulation and metabolism." Journal of neurosurgery 60, no. 5 (1984): 883-908. https://doi.org/10.3171/jns.1984.60.5.0883
Constantin, Peter, and Ciprian Foias. Navier-stokes equations. University of Chicago Press, 2020.
Faber, James E., and George A. Stouffer. "Introduction to basic hemodynamic principles." Cardiovascular hemodynamics for the clinician (2017): 1-16. https://doi.org/10.1002/9781119066491.ch1
Hussain, Mohammad A., Subir Kar, and Ram R. Puniyani. "Relationship between power law coefficients and major blood constituents affecting the whole blood viscosity." Journal of Biosciences 24 (1999): 329-337. https://doi.org/10.1007/BF02941247
Hussain, A., R. R. Puniyani, and S. Kar. "Quantification of blood viscosity using power law model in cerebrovascular accidents and high risk controls." Clinical Hemorheology and Microcirculation 14, no. 5 (1994): 685-696. https://doi.org/10.3233/CH-1994-14507
Rosner, Michael J., Sheila D. Rosner, and Alice H. Johnson. "Cerebral perfusion pressure: management protocol and clinical results." Journal of neurosurgery 83, no. 6 (1995): 949-962. https://doi.org/10.3171/jns.1995.83.6.0949
Raichle, Marcus E., Boyd K. Hartman, John O. Eichling, and Lawrence G. Sharpe. "Central noradrenergic regulation of cerebral blood flow and vascular permeability." Proceedings of the National Academy of Sciences 72, no. 9 (1975): 3726-3730. https://doi.org/10.1073/pnas.72.9.3726
Taqi, Muhammad A., Marc A. Lazzaro, Dhruvil J. Pandya, Aamir Badruddin, and Osama O. Zaidat. "Dissecting aneurysms of posterior cerebral artery: clinical presentation, angiographic findings, treatment, and outcome." Frontiers in Neurology 2 (2011): 38. https://doi.org/10.3389/fneur.2011.00038
