Kinetic and Mechanism of Zerumbone Release from Cross-linked Gelatin-Zeolite Y Hybrid for Oral Anticancer Drug Delivery

Authors

  • Norashikin Salleh Material Science and Technology Programme, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
  • Mohd Muzamir Mahat Material Science and Technology Programme, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
  • Sabrina M. Yahaya Applied Chemistry Programme, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
  • Rosmamuhamadani Ramli Material Science and Technology Programme, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

DOI:

https://doi.org/10.37934/arfmts.115.1.181192

Keywords:

Gelatin, zeolite Y, zerumbone, natural chemotherapy, oral controlled release

Abstract

A hybrid of zeolite Y-gelatin film as an oral dosage form for the natural anticancer drug was achieved by homogenously incorporating the drug-loaded zeolite Y into the gelatin solution. Drug ability was analyzed using computational and experimental approaches, drug encapsulation efficiency via the BET method, and possible interactions by FTIR analyses. Zerumbone released was done in both pH 1.2 and pH 7.4 mimicking the human gastrointestinal tract conditions for 24 hrs and subjected to kinetics study via suitable mathematical models to determine what governs the drug release with the results indicating that a sustained delivery of once-daily oral dosage form could be achieved.

Author Biographies

Norashikin Salleh, Material Science and Technology Programme, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

norashikin406@uitm.edu.my

Mohd Muzamir Mahat, Material Science and Technology Programme, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

mmuzamir@uitm.edu.my

Sabrina M. Yahaya, Applied Chemistry Programme, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

sabrina@uitm.edu.my

Rosmamuhamadani Ramli, Material Science and Technology Programme, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

rosma614@uitm.edu.my

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Published

2024-03-15

How to Cite

Norashikin Salleh, Mohd Muzamir Mahat, Sabrina M. Yahaya, & Rosmamuhamadani Ramli. (2024). Kinetic and Mechanism of Zerumbone Release from Cross-linked Gelatin-Zeolite Y Hybrid for Oral Anticancer Drug Delivery. Journal of Advanced Research in Fluid Mechanics and Thermal Sciences, 115(1), 181–192. https://doi.org/10.37934/arfmts.115.1.181192

Issue

Vol. 115 No. 1: March (2024)

Section

Articles