Coupling Computational Fluid Dynamics and Agent Based Modelling in Analysing the Progression of Stenosis in Blood Flow
DOI:
https://doi.org/10.37934/cfdl.17.1.116Keywords:
Stenosis, Blood Flow, Agent Based Modeling (ABM), Computational Fluid Dynamics (CFD)Abstract
Coronary artery disease is one of the cardiovascular diseases caused by stenosis that forms in the artery due to fatty substances and cholesterol. This condition can lead to death. The development and progression of stenosis significantly depend on the blood flow within the artery. The present study aims to simulate the interaction between the progression of stenosis and blood flow using the Agent-Based Modelling (ABM) technique. ABM, widely utilized in social science and dynamical systems, is applied here to simulate this progression. COMSOL Multiphysics is used to compute the behaviour of blood flow in the artery. The essential data generated, such as wall shear stress, is then incorporated into the ABM to simulate the developmental progression of stenosis. The results reveal that ABM can effectively simulate the progression of stenosis due to blood flow. Additionally, changes in the geometry of the stenosis alter the characteristics of the blood flow passing through it. Understanding the interaction between blood flow and stenosis progression is crucial for developing advanced treatments for coronary artery disease.
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Rabby, Mir Golam, Sumaia Parveen Shupti, and Md Mamun Molla. "Pulsatile non-newtonian laminar blood flows through arterial double stenoses." Journal of Fluids 2014 (2014). https://doi.org/10.1155/2014/757902
Roh, Hyung-Woon, Jae-Soo Kim, and Sang-Ho Suh. "Effects of the velocity waveform of the physiological flow on the hemodynamics in the bifurcated tube." KSME international journal 17 (2003): 296-309. https://doi.org/10.1007/BF02984401
Zaman, Akbar, Nasir Ali, and O. Anwar Bég. "Unsteady magnetohydrodynamic blood flow in a porous-saturated overlapping stenotic artery—numerical modeling." Journal of Mechanics in Medicine and Biology 16, no. 04 (2016): 1650049. https://doi.org/10.1142/S0219519416500494
Biswas, Devajyoti, and Uday Shankar Chakraborty. "Pulsatile flow of blood in a constricted artery with body acceleration." Applications and Applied Mathematics: An International Journal (AAM) 4, no. 2 (2009): 8.
Stroud, J. S., S. A. Berger, and D. Saloner. "Numerical analysis of flow through a severely stenotic carotid artery bifurcation." J. Biomech. Eng. 124, no. 1 (2002): 9-20. https://doi.org/10.1115/1.1427042
Riahi, Daniel N., Ranadhir Roy, and Sam Cavazos. "On arterial blood flow in the presence of an overlapping stenosis." Mathematical and Computer Modelling 54, no. 11-12 (2011): 2999-3006. https://doi.org/10.1016/j.mcm.2011.07.028
Huh, Hyung Kyu, Hojin Ha, and Sang Joon Lee. "Effect of non-Newtonian viscosity on the fluid-dynamic characteristics in stenotic vessels." Experiments in Fluids 56 (2015): 1-12. https://doi.org/10.1007/s00348-015-2037-0
Sousa, Luisa, C. A. T. A. R. I. N. A. Castro, C. A. R. L. O. S. Antonio, and R. Chaves. "Computational techniques and validation of blood flow simulation." WEAS Transactions on biology and biomedicine, ISI/SCI Web of Science and Web of Knowledge 8, no. 04 (2011): 145-155.
Ro, Kyoung-Chul, and Hong-Sun Ryou. "Numerical study on turbulent blood flow in a stenosed artery bifurcation under periodic body acceleration using a modified k-varepsilon model." Korea-Australia Rheology Journal 22, no. 2 (2010): 129-139.
Fullstone, Gavin, Jonathan Wood, Mike Holcombe, and Giuseppe Battaglia. "Modelling the transport of nanoparticles under blood flow using an agent-based approach." Scientific reports 5, no. 1 (2015): 10649. https://doi.org/10.1038/srep10649
Hwang, Minki, Scott A. Berceli, Marc Garbey, Nam Ho Kim, and Roger Tran-Son-Tay. "The dynamics of vein graft remodeling induced by hemodynamic forces: a mathematical model." Biomechanics and modeling in mechanobiology 11 (2012): 411-423. https://doi.org/10.1007/s10237-011-0321-3
Dhange, Mallinath, Gurunath Sankad, Rabia Safdar, Wasim Jamshed, Mohamed R. Eid, Umesh Bhujakkanavar, Soumaya Gouadria, and R. Chouikh. "A mathematical model of blood flow in a stenosed artery with post-stenotic dilatation and a forced field." Plos one 17, no. 7 (2022): e0266727. https://doi.org/10.1371/journal.pone.0266727
Minki Hwang, Marc Garbey, Scott A Berceli, Rongling Wu, Zhihua Jiang, and Roger Tran-Son-Tay. "Rule-based model of vein graft remodeling." PloS one 8, no. 3 (2013): e57822. https://doi.org/10.1371/journal.pone.0057822
Garbey, Marc, and Scott A. Berceli. "A dynamical system that describes vein graft adaptation and failure." Journal of theoretical biology 336 (2013): 209-220. https://doi.org/10.1016/j.jtbi.2013.07.006
Bhui, Rita, and Heather N. Hayenga. "An agent-based model of leukocyte transendothelial migration during atherogenesis." PLoS computational biology 13, no. 5 (2017): e1005523. https://doi.org/10.1371/journal.pcbi.1005523
Garbey, Marc, Stefano Casarin, and Scott A. Berceli. "Vascular adaptation: pattern formation and cross validation between an agent based model and a dynamical system." Journal of theoretical biology 429 (2017): 149-163. https://doi.org/10.1016/j.jtbi.2017.06.013
Garbey, Marc, Stefano Casarin, and Scott A. Berceli. "A versatile hybrid agent-based, particle and partial differential equations method to analyze vascular adaptation." Biomechanics and Modeling in Mechanobiology 18 (2019): 29-44. https://doi.org/10.1007/s10237-018-1065-0
Corti, Anna, Stefano Casarin, Claudio Chiastra, Monika Colombo, Francesco Migliavacca, and Marc Garbey. "A multiscale model of atherosclerotic plaque development: toward a coupling between an agent-based model and CFD simulations." In Computational Science–ICCS 2019: 19th International Conference, Faro, Portugal, June 12–14, 2019, Proceedings, Part IV 19, pp. 410-423. Springer International Publishing, 2019.
Corti, Anna, Claudio Chiastra, Monika Colombo, Marc Garbey, Francesco Migliavacca, and Stefano Casarin. "A fully coupled computational fluid dynamics–agent-based model of atherosclerotic plaque development: multiscale modeling framework and parameter sensitivity analysis." Computers in Biology and Medicine 118 (2020): 103623. https://doi.org/10.1016/j.compbiomed.2020.103623
Saghian, Rojan, Gib Bogle, Joanna L. James, and Alys R. Clark. "Establishment of maternal blood supply to the placenta: insights into plugging, unplugging and trophoblast behaviour from an agent-based model." Interface Focus 9, no. 5 (2019): 20190019. https://doi.org/10.1098/rsfs.2019.0019
Kakhaia, Salome, Pavel Zun, Dongwei Ye, and Valeria Krzhizhanovskaya. "Inverse uncertainty quantification of a mechanical model of arterial tissue with surrogate modelling." Reliability Engineering & System Safety 238 (2023): 109393. https://doi.org/10.1016/j.ress.2023.109393
Schneider, Kay M., Klaudia Giehl, and Stephan A. Baeurle. "Development and application of an agent‐based model for the simulation of the extravasation process of circulating tumor cells." International Journal for Numerical Methods in Biomedical Engineering 39, no. 4 (2023): e3679. https://doi.org/10.1002/cnm.3679
Millar-Wilson, Andrew, Órla Ward, Eolann Duffy, and Gary Hardiman. "Multiscale modeling in the framework of biological systems and its potential for spaceflight biology studies." Iscience 25, no. 11 (2022). https://doi.org/10.1016/j.isci.2022.105421
Jamali, Muhammad Sabaruddin Ahmad, Zuhaila Ismail, and Norsarahaida Saidina Amin. "Effect of different types of stenosis on generalized power law model of blood flow in a bifurcated artery." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 87, no. 3 (2021): 172-183. https://doi.org/10.37934/arfmts.87.3.172183
Zain, Norliza Mohd, and Zuhaila Ismail. "Dynamic Response of Heat Transfer in Magnetohydrodynamic Blood Flow Through a Porous Bifurcated Artery with Overlapping Stenosis." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 101, no. 1 (2023): 215-235. https://doi.org/10.37934/arfmts.101.1.215235
Zain, Norliza Mohd, Zuhaila Ismail, and Peter Johnston. "Numerical Analysis of Blood Flow Behaviour in a Constricted Porous Bifurcated Artery under the Influence of Magnetic Field." CFD Letters 15, no. 1 (2023): 39-58. https://doi.org/10.37934/cfdl.15.1.3958
Ganesh, S., and T. Monika. "MHD effects on unsteady blood flow in a Stenosis." In 2017 International Conference on Innovations in Information, Embedded and Communication Systems (ICIIECS), pp. 1-6. IEEE, 2017.
Zain, Norliza Mohd, and Zuhaila Ismail. "Numerical solution of magnetohydrodynamics effects on a generalised power law fluid model of blood flow through a bifurcated artery with an overlapping shaped stenosis." Plos one 18, no. 2 (2023): e0276576. https://doi.org/10.1371/journal.pone.0276576
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