Synthesis and Characterization of New Cholinium-based Ionic Liquids for Antimicrobial Application

Authors

  • Khairulazhar Jumbri Centre of Research in Ionic Liquids, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, Malaysia
  • Nor Suzy Farahana Mah Noh Department of Chemistry, Faculty of Science, UniversitiPutra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
  • Nur Afiqah Ahmad Department of Fundamental and Applied Sciences, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, Malaysia
  • Mohd Basyaruddin Abdul Rahman Department of Chemistry, Faculty of Science, UniversitiPutra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
  • Haslina Ahmad Department of Chemistry, Faculty of Science, UniversitiPutra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

Keywords:

Antimicrobial , cholinium , ionic liquids , neutralization reaction

Abstract

A series of new cholinium-based ionic liquids (ILs) was synthesized by using simple neutralization reaction. The synthesized ILs were choline 3,5-dinitrosalicylate, choline gallate, choline s-(+)-2-(4-isobutylphenyl)propionate, choline behenate and choline peracetate. All the synthesized cholinium-based ILs were characterized by using FT-IR, 1H and 13C NMR, mass spectrometry, thermogravimetric and differential scanning calorimetry. Result obtained from all characterization techniques confirmed the formation of these cholinium-based ILs. These ILs were then tested for their anti-microbial properties. Anti-microbial test was carried out towards seven types of bacteria which consist of three Gram-positive bacteria, Bacillus subtilis (B29), Staphylococcus aureus (S276), Staphylococcus epidermidis (S273), two Gram-negative bacteria, Pseudomonas aeruginosa (ATCC 15442) and Escherichia coli (E266) and two types of yeasts, Candida albicans (9002) and Candida tropicalis (A3). Streptomycin and Nystatin were used for all bacteria as standard. There is one cholinium-based IL shows excellent inhibition of microbes from growth. Choline peracetate was found to inhibit Candida albicans (9002) as good as the standard, Streptomycin which perform highest of inhibition zone diameter, 25 mm.

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Published

2018-02-15

How to Cite

Khairulazhar Jumbri, Nor Suzy Farahana Mah Noh, Nur Afiqah Ahmad, Mohd Basyaruddin Abdul Rahman, & Haslina Ahmad. (2018). Synthesis and Characterization of New Cholinium-based Ionic Liquids for Antimicrobial Application. Journal of Advanced Research in Fluid Mechanics and Thermal Sciences, 42(1), 16–23. Retrieved from https://semarakilmu.com.my/journals/index.php/fluid_mechanics_thermal_sciences/article/view/2648

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