CFD Analysis of the Choledynamic Flow Characteristics of a Patient with Gallbladder Carcinoma
DOI:
https://doi.org/10.37934/cfdl.17.5.111Keywords:
billiary tree, bile, patient-specific CFD analysis, choledynamicsAbstract
Gallbladder carcinoma (GBC) is a rare malignancy with a low detection rate due to non-specific symptoms, complicating early diagnosis and treatment. This study aims to improve pre-operative and post-operative surgical analysis using patient-specific CFD analysis. CT scan images of a male patient with GBC were segmented using 3D Slicer software, and the biliary tree geometry was imported into ANSYS Workbench for fluid and solid meshing. The mechanical properties of the biliary tree and the rheological properties of bile were determined, with an LRN k-ω model used for simulating the gallbladder refilling stage. Results indicate that unhealthy bile flows slower than healthy bile, suggesting a link between obstructed bile flow and tumors or stones. Tumor-induced blockages cause pressure accumulation in the gallbladder neck, unlike the minimum pressure in healthy cases. These findings highlight the complex interplay between bile rheology, tumor development, and pressure dynamics, suggesting the model’s potential use in surgical planning.
Downloads
References
Roa, Juan C., Patricia García, Vinay K. Kapoor, Shishir K. Maithel, Milind Javle, and Jill Koshiol. "Gallbladder cancer." Nature reviews Disease primers 8, no. 1 (2022): 69. https://doi.org/10.1038/s41572-022-00398-y. DOI: https://doi.org/10.1038/s41572-022-00398-y
Zhou, Yanzhao, Kun Yuan, Yi Yang, Zemin Ji, Dezheng Zhou, Jingzhong Ouyang, Zhengzheng Wang et al., "Gallbladder cancer: current and future treatment options." Frontiers in Pharmacology 14 (2023): 1183619. https://doi.org/10.3389/fphar.2023.1183619 DOI: https://doi.org/10.3389/fphar.2023.1183619
Kuchumov, Alex G., Vasily Vedeneev, Vladimir Samartsev, Aleksandr Khairulin, and Oleg Ivanov. "Patient-specific fluid–structure interaction model of bile flow: comparison between 1-way and 2-way algorithms." Computer Methods in Biomechanics and Biomedical Engineering 24, no. 15 (2021): 1693-1717. https://doi.org/10.1080/10255842.2021.1910942. DOI: https://doi.org/10.1080/10255842.2021.1910942
Kamaltdinov, Marat, Peter Valentinovich Trusov, and Nina Vladimirovna Zaitseva. "Investigation of Digestion Processes in the Stomach and Duodenum using Computational Fluid Dynamics Model." CFD Letters 16, no. 3 (2024): 82-95. https://doi.org/10.37934/cfdl.16.3.8295. DOI: https://doi.org/10.37934/cfdl.16.3.8295
Kuchumov, Aleksey G., Marat R. Kamaltdinov, Vladimir A. Samartsev, Aleksander R. Khairulin, Yulia A. Ivashova, and Redha Taiar. "Patient-specific simulation of a gallbladder refilling based on MRI and ultrasound in vivo measurements." In AIP Conference Proceedings, vol. 2216, no. 1. AIP Publishing, 2020. https://doi.org/10.1063/5.0003367. DOI: https://doi.org/10.1063/5.0003367
Al-Atabi, Mushtak, R. C. Ooi, X. Y. Luo, S. B. Chin, and N. C. Bird. "Computational analysis of the flow of bile in human cystic duct." Medical engineering & physics 34, no. 8 (2012): 1177-1183. https://doi.org/10.1016/j.medengphy.2011.12.006 DOI: https://doi.org/10.1016/j.medengphy.2011.12.006
Kuchumov, Alex G., Valeriy Gilev, Vitaliy Popov, Vladimir Samartsev, and Vasiliy Gavrilov. "Non-Newtonian flow of pathological bile in the biliary system: experimental investigation and CFD simulations." Korea-Australia Rheology Journal 26 (2014): 81-90. https://doi.org/10.1007/s13367-014-0009-1. DOI: https://doi.org/10.1007/s13367-014-0009-1
Peng, Tao, Chenxiao Zhou, Zhexin Zhang, Yingying Liu, Xiaodong Lin, Yunlong Zhong, Ping Wang, and Yanwei Jia. "Bile dynamics within the biliary tract and microfluidic-based bile component detection: A review." arXiv preprint arXiv:2311.13117 (2023). https://doi.org/10.48550/arXiv.2311.13117
Peng, Tao, Yunlong Zhong, Xiaodong Lin, Bingyan Jiang, Ping Wang, and Yanwei Jia. "Analysis and numerical investigation of bile flow dynamics within the strictured biliary duct." International Journal for Numerical Methods in Biomedical Engineering 40, no. 2 (2024): e3790. https://doi.org/10.1002/CNM.3790. DOI: https://doi.org/10.1002/cnm.3790
Nie, Xin, and Lei Li. "A Comparison of Low Reynolds Number k Models." In 4th International Conference on Computer, Mechatronics, Control and Electronic Engineering, pp. 1327-1332. Atlantis Press, 2015. https://doi.org/10.2991/iccmcee-15.2015.250. DOI: https://doi.org/10.2991/iccmcee-15.2015.250
Espinoza, Jaime A., Carolina Bizama, Patricia García, Catterina Ferreccio, Milind Javle, Juan F. Miquel, Jill Koshiol, and Juan C. Roa. "The inflammatory inception of gallbladder cancer." Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1865, no. 2 (2016): 245-254. https://doi.org/10.1016/j.bbcan.2016.03.004. DOI: https://doi.org/10.1016/j.bbcan.2016.03.004
Jones, W. Peter, and Brian Edward Launder. "The prediction of laminarization with a two-equation model of turbulence." International journal of heat and mass transfer 15, no. 2 (1972): 301-314. https://doi.org/10.1016/0017-9310(72)90076-2. DOI: https://doi.org/10.1016/0017-9310(72)90076-2
Luo, X. Y., S. B. Chin, R. C. Ooi, M. Clubb, A. G. Johnson, and N. Bird. "The rheological properties of human bile." In Fourth international conference on fluid mechanics. Dalian, China. 2004..
Ooi, Renn Chan, X. Y. Luo, S. B. Chin, A. G. Johnson, and N. C. Bird. "The flow of bile in the human cystic duct." Journal of biomechanics 37, no. 12 (2004): 1913-1922. https://doi.org/10.1016/j.jbiomech.2004.02.029. DOI: https://doi.org/10.1016/j.jbiomech.2004.02.029
Vassilevski, Yu V., V. Yu Salamatova, and Sergey Sergeevich Simakov. "On the elasticity of blood vessels in one-dimensional problems of hemodynamics." Computational mathematics and mathematical physics 55 (2015): 1567-1578. https://doi.org/10.1134/s0965542515090134 DOI: https://doi.org/10.1134/S0965542515090134
Amabili, Marco, Prabakaran Balasubramanian, Isabella Bozzo, Ivan D. Breslavsky, Giovanni Ferrari, Giulio Franchini, Francesco Giovanniello, and Chloé Pogue. "Nonlinear dynamics of human aortas for material characterization." Physical Review X 10, no. 1 (2020): 011015. https://doi.org/10.1103/physrevx.10.011015. DOI: https://doi.org/10.1103/PhysRevX.10.011015
Luo, Xiaoyu, Wenguang Li, Nigel Bird, Swee Boon Chin, N. A. Hill, and Alan G. Johnson. "On the mechanical behavior of the human biliary system." World Journal of Gastroenterology: WJG 13, no. 9 (2007): 1384. https://doi.org/10.3748/wjg.v13.i9.1384.
Jian, Chunyun, and Gongrui Wang. "Biomechanical study of the bile duct system outside the liver." Bio-Medical Materials and Engineering 1, no. 2 (1991): 105-113. https://doi.org/10.3233/bme-1991-1203. DOI: https://doi.org/10.3233/BME-1991-1203
Zhang, Zhe, and Clement Kleinstreuer. "Low-Reynolds-number turbulent flows in locally constricted conduits: a comparison study." AIAA journal 41, no. 5 (2003): 831-840. https://doi.org/10.2514/2.2044. DOI: https://doi.org/10.2514/2.2044
Luo, Xiaoyu, Wenguang Li, Nigel Bird, Swee Boon Chin, N. A. Hill, and Alan G. Johnson. "On the mechanical behavior of the human biliary system." World Journal of Gastroenterology: WJG 13, no. 9 (2007): 1384. https://doi.org/10.3748/wjg.v13.i9.1384 DOI: https://doi.org/10.3748/wjg.v13.i9.1384
Behar, Jose. "Physiology and pathophysiology of the biliary tract: the gallbladder and sphincter of Oddi—a review." International Scholarly Research Notices 2013, no. 1 (2013): 837630. https://doi.org/10.1155/2013/837630. DOI: https://doi.org/10.1155/2013/837630
Samarrcev, V.A. 2005. Paths of the Improvement of the Cholelithiasis Treatment at the High Operative Risk Group: Optimization of the Diagnostics Methods, Landmark Endoscopic and Less-Invasive Treatment, Predicting and Prophylactics of the Complication. Perm, Russian Federation: Academician EA Wagner Perm State Medical Academy.
Howard, P. J., G. M. Murphy, and R. H. Dowling. "Gall bladder emptying patterns in response to a normal meal in healthy subjects and patients with gall stones: ultrasound study." Gut 32, no. 11 (1991): 1406-1411. https://doi.org/10.1136/gut.32.11.1406. DOI: https://doi.org/10.1136/gut.32.11.1406
Çerçi, Sevim Süreyya, Feride Meltem Özbek, Celal Çerçi, Bahattin Baykal, Hasan Erol Eroğlu, Zeynep Baykal, Mustafa Yıldız, Semahat Sağlam, and Ahmet Yeşildağ. "Gallbladder function and dynamics of bile flow in asymptomatic gallstone disease." World journal of gastroenterology: WJG 15, no. 22 (2009): 2763. https://doi.org/10.3748/wjg.15.2763. DOI: https://doi.org/10.3748/wjg.15.2763
Larsen, Thomas Kjærgaard, and Niels Qvist. "The influence of gallbladder function on the symptomatology in gallstone patients, and the outcome after cholecystectomy or expectancy." Digestive diseases and sciences 52 (2007): 760-763. https://doi.org/10.1007/s10620-006-9498-1. DOI: https://doi.org/10.1007/s10620-006-9498-1
Csendes, A., A. Kruse, Peter Funch-Jensen, M. J. Øster, J. Ørnsholt, and E. Amdrup. "Pressure measurements in the biliary and pancreatic duct systems in controls and in patients with gallstones, previous cholecystectomy, or common bile duct stones." Gastroenterology 77, no. 6 (1979): 1203-1210. https://doi.org/10.1016/0016-5085(79)90158-6. DOI: https://doi.org/10.1016/0016-5085(79)90158-6
Radunovic, Miodrag, Ranko Lazovic, Natasa Popovic, Milorad Magdelinic, Milutin Bulajic, Lenka Radunovic, Marko Vukovic, and Miroslav Radunovic. "Complications of laparoscopic cholecystectomy: our experience from a retrospective analysis." Open access Macedonian journal of medical sciences 4, no. 4 (2016): 641. https://doi.org/10.3889/oamjms.2016.128. DOI: https://doi.org/10.3889/oamjms.2016.128
Taki-Eldin, Ahmed, and Abd-Elnaser Badawy. "Outcome of laparoscopic cholecystectomy in patients with gallstone disease at a secondary level care hospital." ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) 31, no. 01 (2018): e1347. https://doi.org/10.1590/0102-672020180001e1347. DOI: https://doi.org/10.1590/0102-672020180001e1347