Numerical Investigation of Double Emulsion Droplets using Modified Flow Focusing Microfluidic Device for Drug Delivery

Kevin Raynaldo; Ridho Irwansyah

doi:10.37934/cfdl.14.7.3141

Authors

Kevin Raynaldo Laboratory of Fluid Mechanics, Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Depok 16424, West Java, IndonesiaLaboratory of Fluid Mechanics, Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Depok 16424, West Java, Indonesia
Ridho Irwansyah Laboratory of Fluid Mechanics, Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Depok 16424, West Java, Indonesia

DOI:

https://doi.org/10.37934/cfdl.14.7.3141

Keywords:

Double emulsion droplets, Flow focusing microfluidics device, High throughput, Numerical investigation, Drug delivery, VoF

Abstract

Double emulsion droplets generation is convenient for drug delivery applications since the core-shell template has the ability to increase the success of the target and release of the drug. In this study, the modified flow-focusing microfluidics device is proposed to generate double emulsion droplets with high monodispersity and high throughput, satisfying industrial needs. The W/O/W (water-in-oil-in-water) encapsulation template is a common combination in drug delivery. The research aims to analyze double emulsion droplets generation using the 2D Volume of Fluid (VoF) VoF approach, which is able to visualize flow regime, droplets average diameter, Coefficient of Variation (CoV), and droplets generation rate. Combination of water-in-olive oil-in-water was used as the working fluids. The diameter of the droplets, CoV, and generation rate was obtained using image processing. The simulation results showed that the injection model and the sudden expansion in the modified flow-focusing device successfully produced double emulsion droplets with two dripping instabilities. The narrowing jetting flow regime is obtained, including its droplets evolution. The average diameter for both outer and inner droplets were achieved with their CoV, including the generation rate. The outer and inner droplet's diameter generated can potentially be implemented for drug delivery, although the inner droplet's monodispersity must be further investigated. Nevertheless, the proposed device and the flow control were able to generate high-throughput double emulsion droplets.

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Author Biographies

Kevin Raynaldo, Laboratory of Fluid Mechanics, Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Depok 16424, West Java, IndonesiaLaboratory of Fluid Mechanics, Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Depok 16424, West Java, Indonesia

kevin.raynaldo@ui.ac.id

Ridho Irwansyah, Laboratory of Fluid Mechanics, Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Depok 16424, West Java, Indonesia

ridho.irwansyah04@ui.ac.id

References

Sattari, A., P. Hanafizadeh, and M. Hoorfar. "Multiphase flow in microfluidics: From droplets and bubbles to the encapsulated structures." Advances in Colloid and Interface Science 282 (2020). https://doi.org/10.1016/j.cis.2020.102208

Agostini, Matteo, Gina Greco, and Marco Cecchini. "Full-SAW microfluidics-based lab-on-a-chip for biosensing." IEEE Access 7 (2019): 70901-70909. https://doi.org/10.1109/ACCESS.2019.2919000

Chen, Zhuo, Shuang Song, Jing Ma, Si Da Ling, Yun Dong Wang, Tian Tian Kong, and Jian Hong Xu. "Fabrication of magnetic core/shell hydrogels via microfluidics for controlled drug delivery." Chemical Engineering Science 248 (2022): 117216. https://doi.org/10.1016/j.ces.2021.117216.

Isa, Nur Suaidah Mohd, Hani El Kadri, Daniele Vigolo, and Konstantinos Gkatzionis. "Optimisation of bacterial release from a stable microfluidic-generated water-in-oil-in-water emulsion." RSC advances 11, no. 13 (2021): 7738-7749. https://doi.org/10.1039/D0RA10954A

Meng, Xiangkai, Yuanhua Yu, and Guangyong Jin. "Numerical Simulation and Experimental Verification of Droplet Generation in Microfluidic Digital PCR Chip." Micromachines 12, no. 4 (2021): 409. https://doi.org/10.3390/mi12040409

Buryk-Iggers, Stephanie, Jennifer Kieda, and Scott SH Tsai. "Diamagnetic droplet microfluidics applied to single-cell sorting." AIP Advances 9, no. 7 (2019): 075106. https://doi.org/10.1063/1.5095884

Zhi, Zijian, Rui Liu, Wenjun Wang, Koen Dewettinck, and Filip Van Bockstaele. "Recent progress in oil-in-water-in-oil (O/W/O) double emulsions." Critical Reviews in Food Science and Nutrition (2022): 1-12. https://doi.org/10.1080/10408398.2022.2029346

Yu, Wei, Xiangdong Liu, Yuanjin Zhao, and Yongping Chen. "Droplet generation hydrodynamics in the microfluidic cross-junction with different junction angles." Chemical Engineering Science 203 (2019): 259-284. https://doi.org/10.1016/j.ces.2019.03.082

Ramachandran, Ashwin, Diego A. Huyke, Eesha Sharma, Malaya K. Sahoo, ChunHong Huang, Niaz Banaei, Benjamin A. Pinsky, and Juan G. Santiago. "Electric field-driven microfluidics for rapid CRISPR-based diagnostics and its application to detection of SARS-CoV-2." Proceedings of the National Academy of Sciences 117, no. 47 (2020): 29518-29525. https://doi.org/10.1073/pnas.2010254117

Ramezankhani, R., R. Solhi, Y. C. Chai, M. Vosough, and C. Verfaillie. "Organoid and microfluidics-based platforms for drug screening in COVID-19." Drug Discovery Today (2021). doi: https://doi.org/10.1016/j.drudis.2021.12.014.

Chong, DaoTong, XinShi Liu, HuaJie Ma, GuoYou Huang, Yu Long Han, XingYe Cui, JunJie Yan, and Feng Xu. "Advances in fabricating double-emulsion droplets and their biomedical applications." Microfluidics and Nanofluidics 19, no. 5 (2015): 1071-1090. https://doi.org/10.1007/s10404-015-1635-8

Kim, Shin-Hyun, and Bomi Kim. "Controlled formation of double-emulsion drops in sudden expansion channels." Journal of colloid and interface science 415 (2014): 26-31. https://doi.org/10.1016/j.jcis.2013.10.020

Siqueira, Fabio, Hélio Giannini, and Ardson dos S. Vianna. "Droplet formation in oval microchannels with a double T junction: a CFD and experimental study." Brazilian Journal of Chemical Engineering 38, no. 3 (2021): 485-493. https://doi.org/10.1007/s43153-021-00133-2

Zhao-Miao, L. I. U., D. U. Yu, and P. A. N. G. Yan. "Generation of water-in-oil-in-water (W/O/W) double emulsions by microfluidics." Chinese Journal of Analytical Chemistry 46, no. 3 (2018): 324-330. https://doi.org/10.1016/S1872-2040(17)61072-7

Yandrapalli, Naresh, Julien Petit, Oliver Bäumchen, and Tom Robinson. "Surfactant-free production of biomimetic giant unilamellar vesicles using PDMS-based microfluidics." Communications Chemistry 4, no. 1 (2021): 1-10. https://doi.org/10.1038/s42004-021-00530-1

TTan, Shiyao, Cai Gao, Huanyu Liu, Bin Ye, and Dongfang Sun. "Research of double emulsion formation and shell-thickness influence factors in a novel six-way junction microfluidic device." Colloids and Surfaces A: Physicochemical and Engineering Aspects 601 (2020): 124917. https://doi.org/10.1016/j.colsurfa.2020.124917

Fung, Chang Kai, and Mohd Fadhil Majnis. "Computational Fluid Dynamic Simulation Analysis of Effect of Microchannel Geometry on Thermal and Hydraulic Performances of Micro Channel Heat Exchanger." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 62, no. 2 (2019): 198-208.

Azmi, Mohd Irwan Mohd, Nor Azwadi Che Sidik, Yutaka Asako, Wan Mohd Arif Aziz Japar, Nura Muaz Muhammad, and Nadlene Razali. "Numerical Studies on PCM Phase Change Performance in Bricks for Energy-Efficient Building Application–A Review." Journal of Advanced Research in Numerical Heat Transfer 1, no. 1 (2020): 13-21.

Raad, Mohammad, Sajad Rezazadeh, Habib Jalili, and Davod Abbasinezhad Fallah. "A numerical study of droplet splitting in branched T-shaped microchannel using the two-phase level-set method." Advances in Mechanical Engineering 13, no. 11 (2021): 16878140211045487. https://doi.org/10.1177/16878140211045487

Yousofvand, Reza, and Kasra Ghasemi. "A novel microfluidic device for double emulsion formation: The effects of design parameters on droplet production performance." Colloids and Surfaces A: Physicochemical and Engineering Aspects 635 (2022): 128059. https://doi.org/10.1016/j.colsurfa.2021.128059

Sattari, Amirmohammad, Nishat Tasnim, Pedram Hanafizadeh, and Mina Hoorfar. "Numerical study of double emulsion droplet generation in a dual-coaxial microfluidic device using response surface methodology." Chemical Engineering and Processing-Process Intensification 162 (2021): 108330. https://doi.org/10.1016/j.cep.2021.108330.

Ansys, I., ANSYS FLUENT Theory Guide. 2021 R2 ed. Vol. Release 20. 2020. 814-814.

Nabavi, Seyed Ali, Goran T. Vladisavljević, Sai Gu, and Ekanem E. Ekanem. "Double emulsion production in glass capillary microfluidic device: Parametric investigation of droplet generation behaviour." Chemical Engineering Science 130 (2015): 183-196. https://doi.org/10.1016/j.ces.2015.03.004

Seiffert, Sebastian, and Julian Thiele. "Microfluidics." In Microfluidics. De Gruyter, 2019. https://doi.org/10.1515/9783110487701.

Utada, Andrew S., Alberto Fernandez-Nieves, Howard A. Stone, and David A. Weitz. "Dripping to jetting transitions in coflowing liquid streams." Physical review letters 99, no. 9 (2007): 094502. https://doi.org/10.1103/PhysRevLett.99.094502