Optimization of Polyvinylidene Fluoride/Polyvinyl Alcohol Electrospun using Taguchi Method for Tissue Engineering Application

Authors

  • Mohd Syahir Anwar Hamzah Oasis Integrated Group, Institute of Integrated Engineering, Universiti Tun Hussein Onn Malaysia, 86400 Parit Raja, Johor, Malaysia
  • Nadirul Hasraf Mat Nayan Department of Chemical Engineering Technology, Faculty of Engineering Technology, Universiti Tun Hussein Onn Malaysia, KM 1 Jalan Panchor, Pagoh Higher Education Hub, 84600 Panchor, Johor, Malaysia
  • Norhana Jusoh Department of Biomedical Engineering & Health Sciences, Faculty of Electrical Engineering, Universiti Teknologi Malaysia 81310 Skudai, Johor, Malaysia

DOI:

https://doi.org/10.37934/aram.125.1.8192

Keywords:

Taguchi, Electrospinning, Tissue Engineering, Optimization, Nanofibers

Abstract

Composite nanofibers for tissue engineering applications were prepared with polyvinylidene fluoride and polyvinyl alcohol via a horizontal electrospinning process. The effect of the processing parameters (polymer concentration, voltage, feed rate and tip-to-collector distance) on the fibre diameter was studied using L9 orthogonal arrays of the Taguchi Method, S/N ratio, and ANOVA to produce uniform and finest fibre. The optimum parameters were at 90 wt% PVDF ratios for polymer concentration, applied voltage at 10 kV, feed rate at 0.5 mL/h and tip-to-collector distance at 15 cm. The PVDF/PVA electrospun compromises 171.60 nm nanofiber diameter with homogenous morphology and no bead formed. MTT and live/dead kit assay analysis toward human (HSF) cells confirmed the potential of the PVDF/PVA electrospun to be used as an alternative tissue template to allow new cell or tissue formation in the future.

Author Biographies

Mohd Syahir Anwar Hamzah, Oasis Integrated Group, Institute of Integrated Engineering, Universiti Tun Hussein Onn Malaysia, 86400 Parit Raja, Johor, Malaysia

mohdsyahiranwar@gmail.com

Nadirul Hasraf Mat Nayan, Department of Chemical Engineering Technology, Faculty of Engineering Technology, Universiti Tun Hussein Onn Malaysia, KM 1 Jalan Panchor, Pagoh Higher Education Hub, 84600 Panchor, Johor, Malaysia

nadirul@uthm.edu.my

Norhana Jusoh, Department of Biomedical Engineering & Health Sciences, Faculty of Electrical Engineering, Universiti Teknologi Malaysia 81310 Skudai, Johor, Malaysia

norhana@utm.my

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Published

2024-10-02

How to Cite

Anwar Hamzah, M. S. ., Mat Nayan, N. H. ., & Jusoh, N. . (2024). Optimization of Polyvinylidene Fluoride/Polyvinyl Alcohol Electrospun using Taguchi Method for Tissue Engineering Application. Journal of Advanced Research in Applied Mechanics, 125(1), 81–92. https://doi.org/10.37934/aram.125.1.8192

Issue

Vol. 125 No. 1: January (2025)

Section

Articles