Investigation of Digestion Processes in the Stomach and Duodenum using Computational Fluid Dynamics Model
DOI:
https://doi.org/10.37934/cfdl.16.3.8295Keywords:
Numerical simulation, Multiphase flow, Food, Enzymes, AcidityAbstract
The stomach and intestines play an important role in homogenizing the contents of the tract, mixing food with enzymes. The study of digestion processes in a fed state remains difficult by experimental methods. Using computational fluid dynamics models it is possible to obtain flow characteristics at any point in the computational domain. At the previous stages of research, we developed a model to describe the flow of a multiphase multicomponent mixture in the antroduodenum, taking into account the processes of mass transfer between phases, biochemical reactions, mass sources and effluents. In this article, we propose an improvement of the model for describing the multiphase flow in the whole stomach and duodenum, taking into account the gas phase. The mathematical formulation of the problem includes the balance equations of mass and momentum for a multiphase medium with mass sources. Boundary conditions take into account the peristalsis of the tract. In numerical experiments we studied the influence of the density of food particles on the distribution of volume fractions of phases, mass fractions of food components and enzymes, pH level in the digestive tract. In the future, it is necessary to continue working with the rheological properties of the flow.
References
Hunt, R. H., Micheal Camilleri, S. E. Crowe, E. M. El-Omar, J. G. Fox, E. J. Kuipers, Peter Malfertheiner et al. "The stomach in health and disease." Gut 64, no. 10 (2015): 1650-1668. https://doi.org/10.1136/gutjnl-2014-307595
O'Connor, Anthony, and Colm O'Moráin. "Digestive function of the stomach." Digestive diseases 32, no. 3 (2014): 186-191. https://doi.org/10.1159/000357848
Goyal, Raj K., Yanmei Guo, and Hiroshi Mashimo. "Advances in the physiology of gastric emptying." Neurogastroenterology & Motility 31, no. 4 (2019): e13546. https://doi.org/10.1111/nmo.13546
Schulze, K. "Imaging and modelling of digestion in the stomach and the duodenum." Neurogastroenterology & Motility 18, no. 3 (2006): 172-183. https://doi.org/10.1111/j.1365-2982.2006.00759.x
Clarysse, Sarah, Jan Tack, F. Lammert, G. Duchateau, C. Reppas, and Patrick Augustijns. "Postprandial evolution in composition and characteristics of human duodenal fluids in different nutritional states." Journal of pharmaceutical sciences 98, no. 3 (2009): 1177-1192. https://doi.org/10.1002/jps.21502
Makola, Diklar, David A. Peura, and Sheila E. Crowe. "Helicobacter pylori infection and related gastrointestinal diseases." Journal of clinical gastroenterology 41, no. 6 (2007): 548-558. https://doi.org/10.1097/MCG.0b013e318030e3c3
Lacy, Brian E., and Justin Rosemore. "Helicobacter pylori: ulcers and more: the beginning of an era." The Journal of nutrition 131, no. 10 (2001): 2789S-2793S. https://doi.org/10.1093/jn/131.10.2789S
Lu, Pei-Jung, Ping-I. Hsu, Chung-Hsuan Chen, Michael Hsiao, Wei-Chao Chang, Hui-Hwa Tseng, Kung-Hung Lin, Seng-Kee Chuah, and Hui-Chun Chen. "Gastric juice acidity in upper gastrointestinal diseases." World journal of gastroenterology: WJG 16, no. 43 (2010): 5496. https://doi.org/10.3748/wjg.v16.i43.5496
Franke, Andreas, Stephan Teyssen, and Manfred V. Singer. "Alcohol-related diseases of the esophagus and stomach." Digestive diseases 23, no. 3-4 (2006): 204-213. https://doi.org/10.1159/000090167
Li, L. F., R. L. Y. Chan, L. Lu, J. Shen, L. Zhang, W. K. K. Wu, L. Wang, T. Hu, M. X. Li, and C. H. Cho. "Cigarette smoking and gastrointestinal diseases: the causal relationship and underlying molecular mechanisms." International journal of molecular medicine 34, no. 2 (2014): 372-380. https://doi.org/10.3892/ijmm.2014.1786
D’Elia, Lanfranco, Giovanni Rossi, Renato Ippolito, Francesco P. Cappuccio, and Pasquale Strazzullo. "Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies." Clinical nutrition 31, no. 4 (2012): 489-498. https://doi.org/10.1016/j.clnu.2012.01.003
Morrison, Maia EW, Janine M. Joseph, Susan E. McCann, Li Tang, Hani M. Almohanna, and Kirsten B. Moysich. "Cruciferous vegetable consumption and stomach cancer: a case-control study." Nutrition and cancer 72, no. 1 (2020): 52-61. https://doi.org/10.1080/01635581.2019.1615100
Huerta-Franco, María-Raquel, Miguel Vargas-Luna, Paola Tienda, Isabel Delgadillo-Holtfort, Marco Balleza-Ordaz, and Corina Flores-Hernandez. "Effects of occupational stress on the gastrointestinal tract." World journal of gastrointestinal pathophysiology 4, no. 4 (2013): 108. https://doi.org/10.4291/wjgp.v4.i4.108
Greenwald, David A. "Aging, the gastrointestinal tract, and risk of acid-related disease." The American Journal of Medicine Supplements 117, no. 5 (2004): 8-13. https://doi.org/10.1016/j.amjmed.2004.07.019
Beardslee, Luke A., George E. Banis, Sangwook Chu, Sanwei Liu, Ashley A. Chapin, Justin M. Stine, Pankaj Jay Pasricha, and Reza Ghodssi. "Ingestible sensors and sensing systems for minimally invasive diagnosis and monitoring: the next frontier in minimally invasive screening." ACS sensors 5, no. 4 (2020): 891-910. https://doi.org/10.1021/acssensors.9b02263
Lex, Timothy R., Jason D. Rodriguez, Lei Zhang, Wenlei Jiang, and Zongming Gao. "Development of in vitro dissolution testing methods to simulate fed conditions for immediate release solid oral dosage forms." The AAPS Journal 24, no. 2 (2022): 40. https://doi.org/10.1208/s12248-022-00690-5
Ghosh, Tilak, David Ian Lewis, A. T. R. Axon, and S. M. Everett. "methods of measuring gastric acid secretion." Alimentary pharmacology & therapeutics 33, no. 7 (2011): 768-781. https://doi.org/10.1111/j.1365-2036.2010.04573.x
Fois, Chiara Anna Maria, Thi Yen Loan Le, Aaron Schindeler, Sina Naficy, Dale David McClure, Mark Norman Read, Peter Valtchev, Ali Khademhosseini, and Fariba Dehghani. "Models of the Gut for Analyzing the Impact of Food and Drugs." Advanced Healthcare Materials 8, no. 21 (2019): 1900968. https://doi.org/10.1002/adhm.201900968
Kamaltdinov, M. R., and A. G. Kuchumov. "Application of a mathematical model of systemic circulation for determination of blood flow parameters after modified Blalock-Taussig shunt operation in newborns." Russian Journal of Biomechanics 25, no. 3 (2021): 268-284.
Ningappa, Abhilash Hebbandi, Suraj Patil, Gowrava Shenoy Belur, Augustine Benjamin Valerian Barboza, Nitesh Kumar, Raghuvir Pai Ballambat, Adi Azriff Basri, Shah Mohammed Abdul Khader, and Masaaki Tamagawa. "Influence of altered pressures on flow dynamics in carotid bifurcation system using numerical methods." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 97, no. 1 (2022): 47-61. https://doi.org/10.37934/arfmts.97.1.4761
Zin, Ahmad Faiz Mat, Ishkrizat Taib, Muhammad Hanafi Asril Rajo Mantari, Bukhari Manshoor, Ahmad Mubarak Tajul Arifin, Mahmod Abd Hakim Mohamad, Muhammad Sufi Roslan, and Muhammad Rafiuddin Azman. "Temperature Variation with Hemodynamic Effect Simulation on Wall Shear Stress in Fusiform Cerebral Aneurysm." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 95, no. 2 (2022): 40-54. https://doi.org/10.37934/arfmts.95.2.4054
Johari, Nasrul Hadi, M. Hamady, and Xiao Yun Xu. "Fluid-Structure Interaction Study of The Effect of Stent on Local Hemodynamics Parameters at The Stented Carotid Artery Bifurcation." Journal of Advanced Research in Applied Sciences and Engineering Technology 28, no. 2 (2022): 247-255. https://doi.org/10.37934/araset.28.2.247255
Razhali, Nur Farahalya, Ishkrizat Taib, Nurul Fitriah Nasir, Ahmad Mubarak Tajul Arifin, Nor Adrian Nor Salim, Shahrul Azmir Osman, Nofrizal Idris Darlis, and A. K. Kareem. "Analysis of Hemodynamic Effect on Different Stent Strut Configuration in Femoral Popliteal Artery during the Physical and Physiological Conditions." Journal of Advanced Research in Applied Sciences and Engineering Technology 29, no. 1 (2022): 223-236. https://doi.org/10.37934/araset.29.1.223236
Pal, Anupam, Keshavamurthy Indireshkumar, Werner Schwizer, Bertil Abrahamsson, Michael Fried, and James G. Brasseur. "Gastric flow and mixing studied using computer simulation." Proceedings of the Royal Society of London. Series B: Biological Sciences 271, no. 1557 (2004): 2587-2594. https://doi.org/10.1098/rspb.2004.2886
Pal, Anupam, James G. Brasseur, and Bertil Abrahamsson. "A stomach road or “Magenstrasse” for gastric emptying." Journal of biomechanics 40, no. 6 (2007): 1202-1210. https://doi.org/10.1016/j.jbiomech.2006.06.006
Kuhar, Sharun, Jae Ho Lee, Jung-Hee Seo, Pankaj J. Pasricha, and Rajat Mittal. "Effect of stomach motility on food hydrolysis and gastric emptying: Insight from computational models." Physics of Fluids 34, no. 11 (2022): 111909. https://doi.org/10.1063/5.0120933
Li, Changyong, Jie Xiao, Xiao Dong Chen, and Yan Jin. "Mixing and emptying of gastric contents in human-stomach: A numerical study." Journal of biomechanics 118 (2021): 110293. https://doi.org/10.1016/j.jbiomech.2021.110293
Seo, Jung Hee, and Rajat Mittal. "Computational modeling of drug dissolution in the human stomach." Frontiers in Physiology (2022): 2080. https://doi.org/10.3389/fphys.2021.755997
Ebara, Rika, Shunichi Ishida, Taimei Miyagawa, and Yohsuke Imai. "Effects of peristaltic amplitude and frequency on gastric emptying and mixing: a simulation study." Journal of the Royal Society Interface 20, no. 198 (2023): 20220780. https://doi.org/10.1098/rsif.2022.0780
Ferrua, M. J., and R. P. Singh. "Modeling the fluid dynamics in a human stomach to gain insight of food digestion." Journal of food science 75, no. 7 (2010): R151-R162. https://doi.org/10.1111/j.1750-3841.2010.01748.x
Alokaily, Samer, Kathleen Feigl, and Franz X. Tanner. "Characterization of peristaltic flow during the mixing process in a model human stomach." Physics of Fluids 31, no. 10 (2019): 103105. https://doi.org/10.1063/1.5122665
Ferrua, Maria J., Zhengjun Xue, and R. Paul Singh. "On the kinematics and efficiency of advective mixing during gastric digestion–A numerical analysis." Journal of Biomechanics 47, no. 15 (2014): 3664-3673. https://doi.org/10.1016/j.jbiomech.2014.09.033
Hao, Shilei, Bochu Wang, and Yazhou Wang. "Density-dependent gastroretentive microparticles motion in human gastric emptying studied using computer simulation." European Journal of Pharmaceutical Sciences 70 (2015): 72-81. https://doi.org/10.1016/j.ejps.2015.01.009
Xue, Zhengjun, Maria J. Ferrua, and Paul Singh. "Computational fluid dynamics modeling of granular flow in human stomach." Alimentos hoy 21, no. 27 (2012): 3-14.
Ibitoye, S. E., I. K. Adegun, O. A. Olayemi, P. O. Omoniyi, and O. O. Alabi. "Experimental and numerical investigation of flow behaviors of some selected food supplements in modeled intestine." Scientia Iranica 30, no. 1 (2023): 39-51.
Palmada, Nadun, John E. Cater, Leo K. Cheng, and Vinod Suresh. "Experimental and computational studies of peristaltic flow in a duodenal model." Fluids 7, no. 1 (2022): 40. https://doi.org/10.3390/fluids7010040
Zha, Jinping, Siyu Zou, Jianyu Hao, Xinjuan Liu, Guillaume Delaplace, Romain Jeantet, Didier Dupont, Peng Wu, Xiao Dong Chen, and Jie Xiao. "The role of circular folds in mixing intensification in the small intestine: A numerical study." Chemical Engineering Science 229 (2021): 116079. https://doi.org/10.1016/j.ces.2020.116079
Love, R. J., R. G. Lentle, P. Asvarujanon, Y. Hemar, and K. J. Stafford. "An expanded finite element model of the intestinal mixing of digesta." Food Digestion 4 (2013): 26-35. https://doi.org/10.1007/s13228-012-0017-x
Fullard, Luke, Willem Lammers, Graeme C. Wake, and Maria J. Ferrua. "Propagating longitudinal contractions in the ileum of the rabbit–efficiency of advective mixing." Food & function 5, no. 11 (2014): 2731-2742. https://doi.org/10.1039/C4FO00487F
Sinnott, Matthew D., Paul W. Cleary, and Simon M. Harrison. "Peristaltic transport of a particulate suspension in the small intestine." Applied Mathematical Modelling 44 (2017): 143-159. https://doi.org/10.1016/j.apm.2017.01.034
Ploutz-Snyder, Lori, Jeanne Foley, Robert Ploutz-Snyder, Jill Kanaley, Kenneth Sagendorf, and Ronald Meyer. "Gastric gas and fluid emptying assessed by magnetic resonance imaging." European journal of applied physiology and occupational physiology 79 (1999): 212-220. https://doi.org/10.1007/s004210050498
Caballero, N., I. Marin, and J. Serra. "Gastric gas dynamics in healthy humans." Neurogastroenterology & Motility 30, no. 11 (2018): e13408. https://doi.org/10.1111/nmo.13408
Ishida, Shunichi, Taimei Miyagawa, Gregory O'Grady, Leo K. Cheng, and Yohsuke Imai. "Quantification of gastric emptying caused by impaired coordination of pyloric closure with antral contraction: a simulation study." Journal of the Royal Society Interface 16, no. 157 (2019): 20190266. https://doi.org/10.1098/rsif.2019.0266
Imai, Yohsuke, Ikuma Kobayashi, Shunichi Ishida, Takuji Ishikawa, Martin Buist, and Takami Yamaguchi. "Antral recirculation in the stomach during gastric mixing." American Journal of Physiology-Gastrointestinal and Liver Physiology (2013). https://doi.org/10.1152/ajpgi.00350.2012
Trusov, P. V., Nina V. Zaitseva, and M. R. Kamaltdinov. "A multiphase flow in the antroduodenal portion of the gastrointestinal tract: a mathematical model." Computational and Mathematical Methods in Medicine 2016 (2016). https://doi.org/10.1155/2016/5164029
Trusov, P. V., N. V. Zaitseva, M. Yu Tsinker, and A. V. Babuskina. "Modelling dusty air flow in the human resperatory tract." Russian Journal of Biomechanics 22, no. 3 (2018): 262-274.
Trusov, P. V., N. V. Zaitseva, V. M. Chigvintsev, and D. V. Lanin. "MATHEMATICAL MODEL FOR DESCRIBING ANTI-VIRUS IMMUNE RESPONSE REGULATION ALLOWING FOR FUNCTIONAL DISORDERS IN A BODY." Health Risk Analysis 4 (2017): 117-128. https://doi.org/10.21668/health.risk/2017.4.13.eng
Kamaltdinov, M., P. Trusov, and N. Zaitseva. "A mathematical model of the multiphase flow in the antroduodenum: consideration of the digestive enzymes and regulation processes." Series on biomechanics (2018).
Kamaltdinov, Marat R., Peter V. Trusov, and Nina V. Zaitseva. "Viscosity of a multicomponent mixture in the antroduodenum." In AIP Conference Proceedings, vol. 2627, no. 1. AIP Publishing, 2023. https://doi.org/10.1063/5.0117427
Trusov, Petr Valentinovich, Nina Vladimirovna Zaitseva, and Marat Reshidovich Kamaltdinov. "Flow in antroduodenal part of digestive tract: mathematical model and some results." Matematicheskaya Biologiya i Bioinformatika 10, no. 1 (2015): 34-53. https://doi.org/10.17537/2015.10.34
Haruma, Mihara, Okamoto, Kusunoki, Hananoki, Tanaka, Yoshihara, Sumii, and Kajiyama. "Eradication of Helicobacter pylori increases gastric acidity in patients with atrophic gastritis of the corpus—evaluation of 24‐h pH monitoring." Alimentary pharmacology & therapeutics 13, no. 2 (1999): 155-162. https://doi.org/10.1046/j.1365-2036.1999.00459.x
Li, Changyong, and Yan Jin. "Digestion of meat proteins in a human-stomach: A CFD simulation study." Innovative Food Science & Emerging Technologies 83 (2023): 103252. https://doi.org/10.1016/j.ifset.2022.103252
