Pre- and Post-operative Assessment of Bone with Osteogenesis Imperfecta Using Finite Element Analysis: A Review

Abstract

Applications of finite element analysis (FEA) to demonstrate the pre- and post-operative conditions of the brittle bone-related disease known as osteogenesis imperfecta (OI) has been widely used in the past and at present. The method used to reconstruct the bone model that resemble the OI bone geometry plays an important aspect to accurately represent the bone condition to provide more alternative ways to evaluate surgical intervention options. Other factors such as material properties and boundary conditions also reflect the results of the analysis. Therefore, the aim of this review paper is to analyse the approaches of previous studies in terms of model geometry construction, selection of materials properties and boundary conditions to enable a deeper understanding and evaluation of bone fractures in OI patients. The biomechanical design of the intramedullary (IM) rods used in post-operative surgery and the interface between IM rods and bone fragments are also discussed in this review paper.